Characterization of subcellular localization and Ca2+ modulation of calsenilin/DREAM/KChIP3

Ha Na Woo, Jae Woong Chang, Yun Hyung Choi, A. Ryeong Gwon, Yong Keun Jung, Dong Gyu Jo

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Earlier reports found that calsenilin is a transcriptional repressor or a subunit of plasma membrane channel, and indicated that calsenilin was present in the nucleus or plasma membrane. Immunohistochemical and subcellular fractionation analysis, however, revealed that calsenilin/DREAM/KChIP3 was distributed throughout the cytoplasm of SK-N-BE2(C), Jurkat, and HeLa cells. In addition, the expression of calsenilin suppressed the ATP-induced increase in intracellular Ca concentrations. By increase in intracellular calcium concentration, calsenilin was translocated into the nucleus.

Original languageEnglish (US)
Pages (from-to)1193-1197
Number of pages5
JournalNeuroreport
Volume19
Issue number12
DOIs
StatePublished - Aug 6 2008

Keywords

  • Calcium
  • Calsenilin/DREAM/KChIP3
  • Subcellular localization

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