Characterization of rpsL and rrs mutations in streptomycin-resistant Mycobacterium tuberculosis isolates from diverse geographic localities

Srinand Sreevatsan, Xi Pan, Kathryn E. Stockbauer, Diana L. Williams, Barry N. Kreiswirth, James M. Musser

Research output: Contribution to journalComment/debate

143 Scopus citations

Abstract

Two genes (rpsL and rrs) with mutations associated with streptomycin resistance in Mycobacterium tuberculosis were characterized in 78 streptomycin-resistant and 61 streptomycin-susceptible isolates recovered from patients living in the United States, South America, Europe, Africa, and Asia. Fifty-four percent of the 78 resistant organisms had missense mutations in codon 43 of rpsL resulting in a K-43→R substitution. Mutations in codon 88 of rpsL were also identified in four Asian isolates.

Original languageEnglish (US)
Pages (from-to)1024-1026
Number of pages3
JournalAntimicrobial agents and chemotherapy
Volume40
Issue number4
DOIs
StatePublished - Apr 1996

Fingerprint Dive into the research topics of 'Characterization of rpsL and rrs mutations in streptomycin-resistant Mycobacterium tuberculosis isolates from diverse geographic localities'. Together they form a unique fingerprint.

  • Cite this