Characterization of Primary and Secondary Cutaneous B-Cell Lymphomas: A Population-Based Study of 4758 Patients

Daniel O’Leary, Nikhil Goyal, Nathan Rubin, Amrita Goyal-O'Leary

Research output: Contribution to journalArticlepeer-review


Introduction/Background: Cutaneous B-cell lymphomas are a heterogeneous group of rare malignancies whose specific site tropisms and site-specific survival have not been well documented. In this study, we seek to investigate the frequency and survival for primary and secondary cutaneous MZL (pcMZL and scMZL), primary and secondary cutaneous FCL (pcFCL and scFCL), and primary and secondary cutaneous DLBCL (pcDLBCL and scDLBCL) to better understanding their prognosis and natural history. Materials and Methods: A total of 4758 cases of CBCL diagnosed between 1975 and 2016 were identified in the SEER-18 database. Statistical analysis was performed to identify the frequency of location and survival. Results: pcMZL was disproportionately likely to present on the face and upper limb while those of scMZL approximated the expected ratios based on body surface area. pcFCL and scFCL were more likely to present on the face and scalp/neck. pcDLBCL and scDLBCL were more likely to present on the face, scalp/neck, and lower limb. Patients with systemic MZL or FCL, but not DLBCL, had significantly better survival than those diagnosed in the skin than at other sites. Conclusions: All of these lymphomas demonstrate site-specific tropisms and survival. Molecular characterization of cutaneous lymphomas with analyses of tumor microenvironment are the next steps in understanding disease biology.

Original languageEnglish (US)
Pages (from-to)e269-e278
JournalClinical Lymphoma, Myeloma and Leukemia
Issue number4
StatePublished - Apr 2022

Bibliographical note

Funding Information:
This study was funded in part by National Cancer Institute of the National Institutes of Health ( T32 HL007062 ) at the University of Minnesota. Statistical analysis was supported by NIH grant P30 CA77598 and by the National Center for Advancing Translational Sciences of the National Institutes of Health Award Number UL1TR000114 . The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

Publisher Copyright:
© 2021 Elsevier Inc.


  • Cutaneous B-cell lymphoma
  • Epidemiology and end results
  • Primary cutaneous follicle center lymphoma
  • Primary cutaneous marginal zone lymphoma
  • Surveillance
  • primary cutaneous diffuse large B-cell lymphoma

PubMed: MeSH publication types

  • Journal Article
  • Research Support, N.I.H., Extramural


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