Characterization of outer membrane porins expressed by E. coli O157:H7: Observed lowered permeability characteristics and correlation to potential drug targets

Michael B. Martinez, Silvia M. Pulido, Thomas Krick, Lee Ann Higgins, Bruce Witthuhn, Michael Flickinger, Mark R. Emmett, Alan G. Marshall, Gary L. Nelsestuen

Research output: Contribution to conferencePaper

Abstract

The characterization of outer membrane porins expressed by Escherichia coli (E.coli) O157:H7 is discussed. It is found that E.coli, an intestinal bacterium present in beef, is responsible for outbreaks of infection in many parts of the world. Initial infection by E.coli strain O157:H7 occurs when bacteria enter the body through the stomach. A possible contributor to the molecular basis of superior survival may be an altered outer membrane, which creates resistance to acidic stomach pH, bile salts, dilute environments such as well water and other antimicrobial conditions.

Original languageEnglish (US)
Pages345-346
Number of pages2
StatePublished - Dec 1 2002
EventProceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics - Orlando, FL, United States
Duration: Jun 2 2002Jun 6 2002

Other

OtherProceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics
CountryUnited States
CityOrlando, FL
Period6/2/026/6/02

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    Martinez, M. B., Pulido, S. M., Krick, T., Higgins, L. A., Witthuhn, B., Flickinger, M., Emmett, M. R., Marshall, A. G., & Nelsestuen, G. L. (2002). Characterization of outer membrane porins expressed by E. coli O157:H7: Observed lowered permeability characteristics and correlation to potential drug targets. 345-346. Paper presented at Proceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics, Orlando, FL, United States.