Abstract
Natural Deep Eutectic Systems (NADES) composed of sugar and sugar alcohols have been studied and applied in a variety of biological applications. Understanding their interaction with water across dilution and temperature is inherently important for maximizing the utility of NADES. Herein a wide range of sugar:sugar-alcohol molar ratios were synthesized and characterized by viscosity, molar excess volume, differential scanning calorimetry, water activity, and confocal Raman cryomicroscopy. NADES were found to have greater viscosity, reduced heat of fusion, greater absolute molar excess volume, lower water activity, and stronger hydrogen bonding of water than non-NADES mixtures. This is hypothesized to be due to cumulatively stronger hydrogen bonding interactions between components in pure and diluted NADES with the strongest interactions in the water-rich region. This work provides useful data and further understanding of hydrogen bonding interaction strength for a wide range of molar ratios in pure to well-diluted forms.
| Original language | English (US) |
|---|---|
| Article number | 120937 |
| Journal | Journal of Molecular Liquids |
| Volume | 371 |
| DOIs | |
| State | Published - Feb 1 2023 |
Bibliographical note
Funding Information:This study was funded by the US National Institutes of Health [grant number R01HL154734] and the US National Science Foundation [grant number EEC1941543]. Parts of this work were carried out in the Characterization Facility, University of Minnesota, which receives partial support from the US NSF through the MRSEC [Award Number DMR-2011401] and the NNCI [Award Number ECCS-2025124] programs. We thank Dr. Job Ubbink and Dr. Belal Hasan for thoughtful discussions and expertise on water activity and access to their instrumentation.
Publisher Copyright:
© 2022 The Authors
Keywords
- Molar excess volume
- Natural deep eutectic systems
- Raman spectroscopy
- Thermal analysis
- Water activity
PubMed: MeSH publication types
- Journal Article