Abstract
We outline numerical characterization of DNA primary sequence based on calculation of the average distance between pairs of nucleic acid bases. This leads to a representation of DNA by a condensed 4 × 4 symmetrical matrix, the elements of which give the average separation between pair of bases X, Y in DNA (X, Y = A, C, G, T). As an invariant of choice we consider the leading eigenvalue of the derived 4 × 4 matrix. Additional structurally related invariants were obtained by constructing additional "higher order" 4 × 4 matrices derived from the initial 4 × 4 matrix by raising its elements to higher powers. Suitably normalized leading eigenvalue of these matrices offer a novel characterization of DNA primary sequences, referred to as "DNA profiles". The approach is illustrated on exon 1 of human β-globin gene.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 561-568 |
| Number of pages | 8 |
| Journal | Journal of chemical information and computer sciences |
| Volume | 41 |
| Issue number | 3 |
| DOIs | |
| State | Published - Dec 1 2001 |