Characterization of autoxidation products of the antifungal compounds econazole nitrate and miconazole nitrate

Alan R. Oyler, Roxanne E. Naldi, Kevin L. Facchine, David J. Burinsky, Madeleine H. Cozine, Richard Dunphy, J. Douglas Alves-Santana, Mary Lou Cotter

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Econazole nitrate 1 and miconazole nitrate 2 underwent autoxidation in 90% ethanol at 77 °C in the presence of AIBN and oxygen. The benzylic methylene carbons of 1 and 2, the benzylic methine carbon of 2, and the imidazole ring of 2 were sites of oxidation.

Original languageEnglish (US)
Pages (from-to)6549-6560
Number of pages12
JournalTetrahedron
Volume47
Issue number33
DOIs
StatePublished - Aug 12 1991

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    Oyler, A. R., Naldi, R. E., Facchine, K. L., Burinsky, D. J., Cozine, M. H., Dunphy, R., Alves-Santana, J. D., & Lou Cotter, M. (1991). Characterization of autoxidation products of the antifungal compounds econazole nitrate and miconazole nitrate. Tetrahedron, 47(33), 6549-6560. https://doi.org/10.1016/S0040-4020(01)82309-7