Characterization of an autoantigen associated with chronic ulcerative stomatitis: The CUSP autoantigen is a member of the p53 family

Lela A. Lee; Patrick Walsh; Cheryl A. Prater; Lih Jen Su; Angela Marchbank; Timothy B. Egbert; Robert P. Dellavalle; Ira N. Targoff; Kenneth M. Kaufman; Tadeusz P. Chorzelski; Stephania Jablonska

doi:10.1046/j.1523-1747.1999.00651.x

Characterization of an autoantigen associated with chronic ulcerative stomatitis: The CUSP autoantigen is a member of the p53 family

Lela A. Lee, Patrick Walsh, Cheryl A. Prater, Lih Jen Su, Angela Marchbank, Timothy B. Egbert, Robert P. Dellavalle, Ira N. Targoff, Kenneth M. Kaufman, Tadeusz P. Chorzelski, Stephania Jablonska

Research output: Contribution to journal › Article › peer-review

54 Scopus citations

Abstract

A unique clinical syndrome has been described in which patients have chronic oral ulceration and autoantibodies to nuclei of stratified squamous epithelium. We have characterized the autoantibodies from patient sera and found that the major autoantigen is a 70 kDa epithelial nuclear protein. Sequencing of the cDNA for this protein, chronic ulcerative stomatitis protein, revealed it to be homologous to the p53 tumor suppressor and to the p73 putative tumor suppressor, and to be a splicing variant of the KET gene. The p53-like genes, p73 and the several KET splicing variants, are recently described genes of uncertain biologic and pathologic significance. This study provides the first clear association of a p53-like protein with a disease process.

Original language	English (US)
Pages (from-to)	146-151
Number of pages	6
Journal	Journal of Investigative Dermatology
Volume	113
Issue number	2
DOIs	https://doi.org/10.1046/j.1523-1747.1999.00651.x
State	Published - 1999
Externally published	Yes

Keywords

KET
p73
Tumor suppressor

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1046/j.1523-1747.1999.00651.x

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Lee, L. A., Walsh, P., Prater, C. A., Su, L. J., Marchbank, A., Egbert, T. B., Dellavalle, R. P., Targoff, I. N., Kaufman, K. M., Chorzelski, T. P., & Jablonska, S. (1999). Characterization of an autoantigen associated with chronic ulcerative stomatitis: The CUSP autoantigen is a member of the p53 family. Journal of Investigative Dermatology, 113(2), 146-151. https://doi.org/10.1046/j.1523-1747.1999.00651.x

Lee, LA, Walsh, P, Prater, CA, Su, LJ, Marchbank, A, Egbert, TB, Dellavalle, RP, Targoff, IN, Kaufman, KM, Chorzelski, TP & Jablonska, S 1999, 'Characterization of an autoantigen associated with chronic ulcerative stomatitis: The CUSP autoantigen is a member of the p53 family', Journal of Investigative Dermatology, vol. 113, no. 2, pp. 146-151. https://doi.org/10.1046/j.1523-1747.1999.00651.x

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title = "Characterization of an autoantigen associated with chronic ulcerative stomatitis: The CUSP autoantigen is a member of the p53 family",

abstract = "A unique clinical syndrome has been described in which patients have chronic oral ulceration and autoantibodies to nuclei of stratified squamous epithelium. We have characterized the autoantibodies from patient sera and found that the major autoantigen is a 70 kDa epithelial nuclear protein. Sequencing of the cDNA for this protein, chronic ulcerative stomatitis protein, revealed it to be homologous to the p53 tumor suppressor and to the p73 putative tumor suppressor, and to be a splicing variant of the KET gene. The p53-like genes, p73 and the several KET splicing variants, are recently described genes of uncertain biologic and pathologic significance. This study provides the first clear association of a p53-like protein with a disease process.",

keywords = "KET, p73, Tumor suppressor",

author = "Lee, {Lela A.} and Patrick Walsh and Prater, {Cheryl A.} and Su, {Lih Jen} and Angela Marchbank and Egbert, {Timothy B.} and Dellavalle, {Robert P.} and Targoff, {Ira N.} and Kaufman, {Kenneth M.} and Chorzelski, {Tadeusz P.} and Stephania Jablonska",

year = "1999",

doi = "10.1046/j.1523-1747.1999.00651.x",

language = "English (US)",

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T2 - The CUSP autoantigen is a member of the p53 family

AU - Lee, Lela A.

AU - Walsh, Patrick

AU - Prater, Cheryl A.

AU - Su, Lih Jen

AU - Marchbank, Angela

AU - Egbert, Timothy B.

AU - Dellavalle, Robert P.

AU - Targoff, Ira N.

AU - Kaufman, Kenneth M.

AU - Chorzelski, Tadeusz P.

AU - Jablonska, Stephania

PY - 1999

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AB - A unique clinical syndrome has been described in which patients have chronic oral ulceration and autoantibodies to nuclei of stratified squamous epithelium. We have characterized the autoantibodies from patient sera and found that the major autoantigen is a 70 kDa epithelial nuclear protein. Sequencing of the cDNA for this protein, chronic ulcerative stomatitis protein, revealed it to be homologous to the p53 tumor suppressor and to the p73 putative tumor suppressor, and to be a splicing variant of the KET gene. The p53-like genes, p73 and the several KET splicing variants, are recently described genes of uncertain biologic and pathologic significance. This study provides the first clear association of a p53-like protein with a disease process.

KW - KET

KW - p73

KW - Tumor suppressor

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Characterization of an autoantigen associated with chronic ulcerative stomatitis: The CUSP autoantigen is a member of the p53 family

Abstract

Keywords

UN SDGs

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