In order to investigate the selection bias of subjects for inpatient human cocaine studies, characteristics of 859 potential subjects were examined. Excluded subjects compared with accepted group were more likely to be single and male, currently use drugs other than cocaine, have a history of intravenous cocaine use, and have medical or mental health problems or physical complaints. Subjects who were accepted but did not participate, compared with participants, were likely to spend more money on cocaine. These results suggest that potential subjects who were accepted to our research studies may not accurately represent all potential subjects for several important subject characteristics. Copyright (C) 2000 Elsevier Science Ltd.
Bibliographical noteFunding Information:
This research was supported by grants from National Institute on Drug Abuse (P-50 DA09259) and from the National Center for Research Resources (MO1-RR00400). We would like to thank Robin L. Bliss for statistical analysis and Clair Wilcox for preparing the manuscript.
Copyright 2007 Elsevier B.V., All rights reserved.
- Research subjects
- Selection bias