Characteristics of participants at baseline in the Treatment of Mild Hypertension Study (TOMHS)

Stephen R. Mascioli; Richard H. Grimm; James D. Neaton; Jeremiah Stamler; Ronald J. Prineas; Jeffrey A. Cutler; Patricia J. Elmer; Robert McDonald; Harold Schnaper; James Schoenberger

doi:10.1016/0002-9149(90)90760-X

Characteristics of participants at baseline in the Treatment of Mild Hypertension Study (TOMHS)

Stephen R. Mascioli
, Richard H. Grimm
, James D. Neaton
, Jeremiah Stamler
, Ronald J. Prineas
, Jeffrey A. Cutler
, Patricia J. Elmer
, Robert McDonald
, Harold Schnaper
, James Schoenberger

Biostatistics

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

The Treatment of Mild Hypertension Study (TOMHS) is a randomized, double-blind clinical trial currently being conducted to compare the effects of nonpharmacologic therapy alone with those of 1 of 5 active drug regimens combined with nonpharmacologic therapy, for long-term management of patients with mild hypertension. Six classes of drugs were studied: (1) acebutolol (β blocker), (2) amlodipine (calcium antagonist), (3) chlorthalidone (diuretic), (4) dpxazosin (α₁ antagonist), (5) enalapril (angiotensin-converting enzyme inhibitor) and (6) placebo. All participants received nutritional-hygienic advice to reduce weight and sodium and alcohol intakes and to increase physical activity. End points include blood pressure change, side effects and quality-of-life indices; incidence of electrocardiographic and echocardiographic abnormalities; and incidence of cardiovascular clinical events, including death, among participants receiving drugs as first-step treatment as well as nonpharmacologic treatment compared with incidence among those participants randomized to nonpharmacologic treatment only as the initial step.

Original language	English (US)
Pages (from-to)	C32-C35
Journal	The American Journal of Cardiology
Volume	66
Issue number	9
DOIs	https://doi.org/10.1016/0002-9149(90)90760-X
State	Published - Sep 25 1990

Bibliographical note

Funding Information:
From the Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, Minnesota. This study is being supported in part by a grant from the National Heart, Lung, and Blood Institute, Beth&a, Maryland, and grants from Boehringer Ingelheim Pharmaceuticals, Inc., Merck Sharp and Dohme, Pfizer Pharmaceuticals. and Wyeth-Aycrst Laboratories.

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title = "Characteristics of participants at baseline in the Treatment of Mild Hypertension Study (TOMHS)",

abstract = "The Treatment of Mild Hypertension Study (TOMHS) is a randomized, double-blind clinical trial currently being conducted to compare the effects of nonpharmacologic therapy alone with those of 1 of 5 active drug regimens combined with nonpharmacologic therapy, for long-term management of patients with mild hypertension. Six classes of drugs were studied: (1) acebutolol (β blocker), (2) amlodipine (calcium antagonist), (3) chlorthalidone (diuretic), (4) dpxazosin (α1 antagonist), (5) enalapril (angiotensin-converting enzyme inhibitor) and (6) placebo. All participants received nutritional-hygienic advice to reduce weight and sodium and alcohol intakes and to increase physical activity. End points include blood pressure change, side effects and quality-of-life indices; incidence of electrocardiographic and echocardiographic abnormalities; and incidence of cardiovascular clinical events, including death, among participants receiving drugs as first-step treatment as well as nonpharmacologic treatment compared with incidence among those participants randomized to nonpharmacologic treatment only as the initial step.",

author = "Mascioli, \{Stephen R.\} and Grimm, \{Richard H.\} and Neaton, \{James D.\} and Jeremiah Stamler and Prineas, \{Ronald J.\} and Cutler, \{Jeffrey A.\} and Elmer, \{Patricia J.\} and Robert McDonald and Harold Schnaper and James Schoenberger",

note = "Funding Information: From the Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, Minnesota. This study is being supported in part by a grant from the National Heart, Lung, and Blood Institute, Beth\&a, Maryland, and grants from Boehringer Ingelheim Pharmaceuticals, Inc., Merck Sharp and Dohme, Pfizer Pharmaceuticals. and Wyeth-Aycrst Laboratories.",

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AU - Mascioli, Stephen R.

AU - Grimm, Richard H.

AU - Neaton, James D.

AU - Stamler, Jeremiah

AU - Prineas, Ronald J.

AU - Cutler, Jeffrey A.

AU - Elmer, Patricia J.

AU - McDonald, Robert

AU - Schnaper, Harold

AU - Schoenberger, James

N1 - Funding Information: From the Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, Minnesota. This study is being supported in part by a grant from the National Heart, Lung, and Blood Institute, Beth&a, Maryland, and grants from Boehringer Ingelheim Pharmaceuticals, Inc., Merck Sharp and Dohme, Pfizer Pharmaceuticals. and Wyeth-Aycrst Laboratories.

PY - 1990/9/25

Y1 - 1990/9/25

N2 - The Treatment of Mild Hypertension Study (TOMHS) is a randomized, double-blind clinical trial currently being conducted to compare the effects of nonpharmacologic therapy alone with those of 1 of 5 active drug regimens combined with nonpharmacologic therapy, for long-term management of patients with mild hypertension. Six classes of drugs were studied: (1) acebutolol (β blocker), (2) amlodipine (calcium antagonist), (3) chlorthalidone (diuretic), (4) dpxazosin (α1 antagonist), (5) enalapril (angiotensin-converting enzyme inhibitor) and (6) placebo. All participants received nutritional-hygienic advice to reduce weight and sodium and alcohol intakes and to increase physical activity. End points include blood pressure change, side effects and quality-of-life indices; incidence of electrocardiographic and echocardiographic abnormalities; and incidence of cardiovascular clinical events, including death, among participants receiving drugs as first-step treatment as well as nonpharmacologic treatment compared with incidence among those participants randomized to nonpharmacologic treatment only as the initial step.

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ER -

Characteristics of participants at baseline in the Treatment of Mild Hypertension Study (TOMHS)

Abstract

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