Characteristics of NK cell migration early after vaccinia infection

Martin Prlic, James Gibbs, Stephen C. Jameson

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

NK cells are critical components in innate immunity, yet little is known about their migration and proliferation during infection. In this report we study the early NK response toward vaccinia. We observed NK migration into the infected peritoneum as early as 6 h after vaccinia inoculation. Interestingly, although NK trafficking to the infected peritoneum depended on Gαi protein-coupled receptors, trafficking to other tissues (including lung, liver, spleen, and bone marrow) did not. We found that despite a dramatic increase in NK numbers at the primary site of infection, their in situ proliferation was low compared with that at other tissue locations. These features are similar to those found for Ag-experienced T cells, suggesting similar patterns of trafficking and proliferation for these lymphocyte subsets.

Original languageEnglish (US)
Pages (from-to)2152-2157
Number of pages6
JournalJournal of Immunology
Volume175
Issue number4
DOIs
StatePublished - Aug 15 2005

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