Characteristics of Cancer-Related Fatigue and Concomitant Sleep Disturbance in Cancer Patients

Ivan H C Wu; Diwakar D Balachandran; Saadia A Faiz; Lara Bashoura; Carmen P Escalante; Ellen F Manzullo

doi:10.1016/j.jpainsymman.2021.07.025

Characteristics of Cancer-Related Fatigue and Concomitant Sleep Disturbance in Cancer Patients

Ivan H C Wu, Diwakar D Balachandran, Saadia A Faiz, Lara Bashoura, Carmen P Escalante, Ellen F Manzullo

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

CONTEXT: Cancer patients often experience cancer-related fatigue (CRF) and sleep disturbances due to cancer and cancer treatment, and symptoms can persist long after treatment. Despite these common occurrences, few studies simultaneously characterize CRF and sleep architecture among cancer patients.

OBJECTIVES: The objective was to characterize CRF and the sleep architecture of patients seen in a CRF clinic and sleep clinic at the University of Texas MD Anderson Cancer Center.

METHODS: CRF Clinic medical records were retrospectively reviewed from September 1, 2006, to September 30, 2010, for self-reported performance status, fatigue, pain, sleep disturbance, depression, anxiety, and sleepiness (n = 219). Polysomnography results were recorded for those referred for additional sleep consultation (n = 39).

RESULTS: Notably, patients often reported fatigue, sleep disturbance, excessive daytime sleepiness, and a majority of patients referred for a sleep consultation were diagnosed with obstructive sleep apnea (n = 33).

CONCLUSION: The results highlight the promise of an interdisciplinary collaboration between dedicated a CRF clinic and sleep clinic to conduct effective assessments to identify treatable CRF and sleep disorders.

Original language	English (US)
Pages (from-to)	e1-e8
Journal	Journal of Pain and Symptom Management
Volume	63
Issue number	1
DOIs	https://doi.org/10.1016/j.jpainsymman.2021.07.025
State	Published - Jan 2022
Externally published	Yes

Bibliographical note

Funding Information:
The authors have no financial relationships to disclose. IHWU held a K99/R00 Pathway to Independence Award ( K99MD015296 ), and a fellowship funded by the Cancer Prevention & Research Institute of Texas ( RP170259 ; principal investigators, Shine Chang and Sanjay Shete), the NIH/NCI ( P30CA016672 ), and Lorna H. McNeill, Ph.D. The authors thank the MD Anderson Cancer Center Scientific Publications, Research Medical Library for editing the manuscript.

Publisher Copyright:
© 2021 American Academy of Hospice and Palliative Medicine

Keywords

Disorders of Excessive Somnolence/diagnosis
Fatigue/diagnosis
Humans
Neoplasms/complications
Polysomnography
Retrospective Studies
Sleep
Sleep Wake Disorders/diagnosis
sleep disturbance
sleep disorder
cancer
polysomnography
Cancer related fatigue

PubMed: MeSH publication types

Research Support, Non-U.S. Gov't
Journal Article
Research Support, N.I.H., Extramural

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jpainsymman.2021.07.025

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title = "Characteristics of Cancer-Related Fatigue and Concomitant Sleep Disturbance in Cancer Patients",

abstract = "CONTEXT: Cancer patients often experience cancer-related fatigue (CRF) and sleep disturbances due to cancer and cancer treatment, and symptoms can persist long after treatment. Despite these common occurrences, few studies simultaneously characterize CRF and sleep architecture among cancer patients.OBJECTIVES: The objective was to characterize CRF and the sleep architecture of patients seen in a CRF clinic and sleep clinic at the University of Texas MD Anderson Cancer Center.METHODS: CRF Clinic medical records were retrospectively reviewed from September 1, 2006, to September 30, 2010, for self-reported performance status, fatigue, pain, sleep disturbance, depression, anxiety, and sleepiness (n = 219). Polysomnography results were recorded for those referred for additional sleep consultation (n = 39).RESULTS: Notably, patients often reported fatigue, sleep disturbance, excessive daytime sleepiness, and a majority of patients referred for a sleep consultation were diagnosed with obstructive sleep apnea (n = 33).CONCLUSION: The results highlight the promise of an interdisciplinary collaboration between dedicated a CRF clinic and sleep clinic to conduct effective assessments to identify treatable CRF and sleep disorders.",

keywords = "Disorders of Excessive Somnolence/diagnosis, Fatigue/diagnosis, Humans, Neoplasms/complications, Polysomnography, Retrospective Studies, Sleep, Sleep Wake Disorders/diagnosis, sleep disturbance, sleep disorder, cancer, polysomnography, Cancer related fatigue",

author = "Wu, {Ivan H C} and Balachandran, {Diwakar D} and Faiz, {Saadia A} and Lara Bashoura and Escalante, {Carmen P} and Manzullo, {Ellen F}",

note = "Funding Information: The authors have no financial relationships to disclose. IHWU held a K99/R00 Pathway to Independence Award ( K99MD015296 ), and a fellowship funded by the Cancer Prevention & Research Institute of Texas ( RP170259 ; principal investigators, Shine Chang and Sanjay Shete), the NIH/NCI ( P30CA016672 ), and Lorna H. McNeill, Ph.D. The authors thank the MD Anderson Cancer Center Scientific Publications, Research Medical Library for editing the manuscript. Publisher Copyright: {\textcopyright} 2021 American Academy of Hospice and Palliative Medicine",

year = "2022",

month = jan,

doi = "10.1016/j.jpainsymman.2021.07.025",

language = "English (US)",

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journal = "Journal of Pain and Symptom Management",

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AU - Wu, Ivan H C

AU - Balachandran, Diwakar D

AU - Faiz, Saadia A

AU - Bashoura, Lara

AU - Escalante, Carmen P

AU - Manzullo, Ellen F

N1 - Funding Information: The authors have no financial relationships to disclose. IHWU held a K99/R00 Pathway to Independence Award ( K99MD015296 ), and a fellowship funded by the Cancer Prevention & Research Institute of Texas ( RP170259 ; principal investigators, Shine Chang and Sanjay Shete), the NIH/NCI ( P30CA016672 ), and Lorna H. McNeill, Ph.D. The authors thank the MD Anderson Cancer Center Scientific Publications, Research Medical Library for editing the manuscript. Publisher Copyright: © 2021 American Academy of Hospice and Palliative Medicine

PY - 2022/1

Y1 - 2022/1

N2 - CONTEXT: Cancer patients often experience cancer-related fatigue (CRF) and sleep disturbances due to cancer and cancer treatment, and symptoms can persist long after treatment. Despite these common occurrences, few studies simultaneously characterize CRF and sleep architecture among cancer patients.OBJECTIVES: The objective was to characterize CRF and the sleep architecture of patients seen in a CRF clinic and sleep clinic at the University of Texas MD Anderson Cancer Center.METHODS: CRF Clinic medical records were retrospectively reviewed from September 1, 2006, to September 30, 2010, for self-reported performance status, fatigue, pain, sleep disturbance, depression, anxiety, and sleepiness (n = 219). Polysomnography results were recorded for those referred for additional sleep consultation (n = 39).RESULTS: Notably, patients often reported fatigue, sleep disturbance, excessive daytime sleepiness, and a majority of patients referred for a sleep consultation were diagnosed with obstructive sleep apnea (n = 33).CONCLUSION: The results highlight the promise of an interdisciplinary collaboration between dedicated a CRF clinic and sleep clinic to conduct effective assessments to identify treatable CRF and sleep disorders.

AB - CONTEXT: Cancer patients often experience cancer-related fatigue (CRF) and sleep disturbances due to cancer and cancer treatment, and symptoms can persist long after treatment. Despite these common occurrences, few studies simultaneously characterize CRF and sleep architecture among cancer patients.OBJECTIVES: The objective was to characterize CRF and the sleep architecture of patients seen in a CRF clinic and sleep clinic at the University of Texas MD Anderson Cancer Center.METHODS: CRF Clinic medical records were retrospectively reviewed from September 1, 2006, to September 30, 2010, for self-reported performance status, fatigue, pain, sleep disturbance, depression, anxiety, and sleepiness (n = 219). Polysomnography results were recorded for those referred for additional sleep consultation (n = 39).RESULTS: Notably, patients often reported fatigue, sleep disturbance, excessive daytime sleepiness, and a majority of patients referred for a sleep consultation were diagnosed with obstructive sleep apnea (n = 33).CONCLUSION: The results highlight the promise of an interdisciplinary collaboration between dedicated a CRF clinic and sleep clinic to conduct effective assessments to identify treatable CRF and sleep disorders.

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KW - Neoplasms/complications

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KW - Retrospective Studies

KW - Sleep

KW - Sleep Wake Disorders/diagnosis

KW - sleep disturbance

KW - sleep disorder

KW - cancer

KW - polysomnography

KW - Cancer related fatigue

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ER -

Characteristics of Cancer-Related Fatigue and Concomitant Sleep Disturbance in Cancer Patients

Abstract

Bibliographical note

Keywords

PubMed: MeSH publication types

UN SDGs

Publisher link

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