Characteristics of adults in the hepatitis b research network in North America reflect their country of origin and hepatitis B virus genotype

Marc G. Ghany, Robert Perrillo, Ruosha Li, Steven H. Belle, Harry L A Janssen, Norah A. Terrault, Margaret C. Shuhart, Daryl T Y Lau, W. Ray Kim, Michael W. Fried, Richard K. Sterling, Adrian M. Di Bisceglie, Steven Huy B Han, Lilia Milkova Ganova-Raeva, Kyong Mi Chang, Anna Suk Fong Lok, Raymond T. Chung, Lewis R. Roberts, Coleman I. Smith, Mauricio Lisker-MelmanDavid K. Wong, Joshua Juan, Jordan Feld, Colina Yim, Jenny Heathcoate, William M. Lee, Son Do, Tram T. Tran, Mandana Khalili, Stewart L. Cooper, Robert J. Fontana, Naoky Tsai, Keyur Patel, Donna Evon, Robert C. Carithers, Kris V. Kowdley, Chia C. Wang, T. Jake Liang, Jang June Park, Abdus Wahed, David Kleiner, Nezam Afdhal, Asad Javaid, Jianghe Niu, Johanna Han, Imad Nasser, Alisha C. Stahler, Linda Stadheim, Mohamed Hassan, Debra L. King, Rosemary A. Nagy, Danie La, Lucie Liu, Stacey Minshall, Sheila Bass, Samuel French, Velma Peacock, Ashley Ungermann, Claudia Ayala, Emma Olson, Ivy Lau, Veronika Podolskaya, Nata DeVole, Barbara McKenna, Kelly Oberhelman, Sravanthi Kaza, Cassandra Rodd, Leslie Huddleston, Peter Poerzgen, Jama M. Darling, A. Sidney Barritt, Tiffany Marsh, Vikki Metheny, Danielle Cardona, Velimir A. Luketic, Paula G. Smith, Charlotte Hofmann, Terri Mathisen, Susan Strom, Jody Mooney, Lupita Cardona-Gonzalez, Nancy Fryzek, Elenita Rivera, Nevitt Morris, Vanessa Haynes-Williams, Mary E. Valiga, Keith Torrey, Danielle Levine, James Keith, Michael Betts, Luis J. Montaner, Chong Gee Teo, Yury Khudyakov, Lili T. Punkova, Yona Cloonan, Michelle Danielson, Tamara Haller, Geoffrey Johnson, Stephanie Kelley, Sharon Lawlor, Manuel Lombardero, Joan M. MacGregor, Andrew Pelesko, Donna Stoliker, Barbara Walters, Ella Zadorozny

Research output: Contribution to journalArticle

45 Scopus citations

Abstract

Background & Aims: Chronic hepatitis B virus (HBV) infection is an important cause of cirrhosis and hepatocellular carcinoma worldwide; populations that migrate to the United States and Canada might be affected disproportionately. The Hepatitis B Research Network (HBRN) is a cooperative network of investigators from the United States and Canada, created to facilitate clinical, therapeutic, and translational research in adults and children with hepatitis B. We describe the structure of the network and baseline characteristics of adults with hepatitis B enrolled in the network. Methods: The HBRN collected data on the clinical characteristics of 1625 adults with chronic HBV infection who are not receiving antiviral therapy from 21 clinical centers in North America. Results: Half of the subjects in the HBRN are men, and the median age is 42 years; 72% are Asian, 15% are black, and 11% are white; with 82% born outside of North America. The most common HBV genotype was B (39%); 74% of subjects were negative for the hepatitis B e antigen. The median serum level of HBV DNA when the study began was 3.6 log10 IU/mL; 68% of male subjects and 67% of female subjects had alanine aminotransferase levels higher than the normal range. Conclusions: The HBRN cohort is used to address important clinical and therapeutic questions for North Americans infected with chronic HBV and to guide health policies on HBV prevention and management in North America.

Original languageEnglish (US)
Pages (from-to)183-192
Number of pages10
JournalClinical Gastroenterology and Hepatology
Volume13
Issue number1
DOIs
StatePublished - Jan 1 2015

Keywords

  • ALT
  • Chronic hepatitis B virus infection
  • HBeAg
  • USA

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    Ghany, M. G., Perrillo, R., Li, R., Belle, S. H., Janssen, H. L. A., Terrault, N. A., Shuhart, M. C., Lau, D. T. Y., Kim, W. R., Fried, M. W., Sterling, R. K., Di Bisceglie, A. M., Han, S. H. B., Ganova-Raeva, L. M., Chang, K. M., Lok, A. S. F., Chung, R. T., Roberts, L. R., Smith, C. I., ... Zadorozny, E. (2015). Characteristics of adults in the hepatitis b research network in North America reflect their country of origin and hepatitis B virus genotype. Clinical Gastroenterology and Hepatology, 13(1), 183-192. https://doi.org/10.1016/j.cgh.2014.06.028