Chapter 5.5 Microdialysis in pain research

Carl Olav Stiller, Ernst Brodin, Bradley K. Taylor

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

In vivo microdialysis has aided preclinical pain research for more than a decade. This valuable tool has allowed correlations between behavioral signs of pain and CNS neurotransmitter release. Here, we review studies that describe the effects of noxious stimulation on neurotransmitter concentrations in microdialysate obtained from either spinal cord or pain modulatory centers in the brain. We conclude that such studies are currently evolving from models of acute pain to a more modern approach that assesses release in animal models of lasting painful conditions.

Original languageEnglish (US)
Title of host publicationHandbook of Microdialysis Methods, Applications and Perspectives
EditorsBen Westerink, Thomas Cremers
Pages473-481
Number of pages9
DOIs
StatePublished - Dec 1 2006

Publication series

NameHandbook of Behavioral Neuroscience
Volume16
ISSN (Print)1569-7339

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