Changing the paradigm: the potential for targeted therapy in laryngeal squamous cell carcinoma

Megan L. Ludwig; Andrew C. Birkeland; Rebecca Hoesli; Paul Swiecicki; Matthew E. Spector; J. Chad Brenner

doi:10.28092/j.issn.2095-3941.2016.0010

Changing the paradigm: the potential for targeted therapy in laryngeal squamous cell carcinoma

Megan L. Ludwig, Andrew C. Birkeland, Rebecca Hoesli, Paul Swiecicki, Matthew E. Spector, J. Chad Brenner

Research output: Contribution to journal › Review article › peer-review

30 Scopus citations

Abstract

Laryngeal squamous cell carcinoma (LSCC) remains a highly morbid and fatal disease. Historically, it has been a model example for organ preservation and treatment stratification paradigms. Unfortunately, survival for LSCC has stagnated over the past few decades. As the era of next-generation sequencing and personalized treatment for cancer approaches, LSCC may be an ideal disease for consideration of further treatment stratification and personalization. Here, we will discuss the important history of LSCC as a model system for organ preservation, unique and potentially targetable genetic signatures of LSCC, and methods for bringing stratified, personalized treatment strategies to the 21st century.

Original language	English (US)
Pages (from-to)	87-100
Number of pages	14
Journal	Cancer Biology and Medicine
Volume	13
Issue number	1
DOIs	https://doi.org/10.28092/j.issn.2095-3941.2016.0010
State	Published - Mar 1 2016
Externally published	Yes

Bibliographical note

Publisher Copyright:
Copyright © 2016 by Cancer Biology & Medicine.

Keywords

Genetics
Head and neck cancer
Laryngeal squamous cell carcinoma
Personalized medicine
Targeted therapy

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Publisher link

10.28092/j.issn.2095-3941.2016.0010

Find It

Find It at U of M Libraries

Cite this

@article{eaa61da3f6794c75b95053a0dfff6a89,

title = "Changing the paradigm: the potential for targeted therapy in laryngeal squamous cell carcinoma",

abstract = "Laryngeal squamous cell carcinoma (LSCC) remains a highly morbid and fatal disease. Historically, it has been a model example for organ preservation and treatment stratification paradigms. Unfortunately, survival for LSCC has stagnated over the past few decades. As the era of next-generation sequencing and personalized treatment for cancer approaches, LSCC may be an ideal disease for consideration of further treatment stratification and personalization. Here, we will discuss the important history of LSCC as a model system for organ preservation, unique and potentially targetable genetic signatures of LSCC, and methods for bringing stratified, personalized treatment strategies to the 21st century.",

keywords = "Genetics, Head and neck cancer, Laryngeal squamous cell carcinoma, Personalized medicine, Targeted therapy",

author = "Ludwig, {Megan L.} and Birkeland, {Andrew C.} and Rebecca Hoesli and Paul Swiecicki and Spector, {Matthew E.} and {Chad Brenner}, J.",

note = "Publisher Copyright: Copyright {\textcopyright} 2016 by Cancer Biology & Medicine.",

year = "2016",

month = mar,

day = "1",

doi = "10.28092/j.issn.2095-3941.2016.0010",

language = "English (US)",

volume = "13",

pages = "87--100",

journal = "Cancer Biology and Medicine",

issn = "2095-3941",

publisher = "Cancer Biology and Medicine",

number = "1",

}

TY - JOUR

T1 - Changing the paradigm

T2 - the potential for targeted therapy in laryngeal squamous cell carcinoma

AU - Ludwig, Megan L.

AU - Birkeland, Andrew C.

AU - Hoesli, Rebecca

AU - Swiecicki, Paul

AU - Spector, Matthew E.

AU - Chad Brenner, J.

PY - 2016/3/1

Y1 - 2016/3/1

N2 - Laryngeal squamous cell carcinoma (LSCC) remains a highly morbid and fatal disease. Historically, it has been a model example for organ preservation and treatment stratification paradigms. Unfortunately, survival for LSCC has stagnated over the past few decades. As the era of next-generation sequencing and personalized treatment for cancer approaches, LSCC may be an ideal disease for consideration of further treatment stratification and personalization. Here, we will discuss the important history of LSCC as a model system for organ preservation, unique and potentially targetable genetic signatures of LSCC, and methods for bringing stratified, personalized treatment strategies to the 21st century.

AB - Laryngeal squamous cell carcinoma (LSCC) remains a highly morbid and fatal disease. Historically, it has been a model example for organ preservation and treatment stratification paradigms. Unfortunately, survival for LSCC has stagnated over the past few decades. As the era of next-generation sequencing and personalized treatment for cancer approaches, LSCC may be an ideal disease for consideration of further treatment stratification and personalization. Here, we will discuss the important history of LSCC as a model system for organ preservation, unique and potentially targetable genetic signatures of LSCC, and methods for bringing stratified, personalized treatment strategies to the 21st century.

KW - Genetics

KW - Head and neck cancer

KW - Laryngeal squamous cell carcinoma

KW - Personalized medicine

KW - Targeted therapy

UR - http://www.scopus.com/inward/record.url?scp=84969247915&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84969247915&partnerID=8YFLogxK

U2 - 10.28092/j.issn.2095-3941.2016.0010

DO - 10.28092/j.issn.2095-3941.2016.0010

M3 - Review article

AN - SCOPUS:84969247915

SN - 2095-3941

VL - 13

SP - 87

EP - 100

JO - Cancer Biology and Medicine

JF - Cancer Biology and Medicine

IS - 1

ER -

Changing the paradigm: the potential for targeted therapy in laryngeal squamous cell carcinoma

Abstract

Bibliographical note

Keywords

UN SDGs

Publisher link

Find It

Other files and links

Fingerprint

Cite this