Changes with age in the time structure of blood pressure

Germaine Cornelissen, Jarmila Siegelova, Alena Havelkova, Leona Dunklerova, Jiri Dusek

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


To map changes in the time structure of blood pressure as a function of age, we analyze 7-day/24-hour records obtained by ambulatory blood pressure monitoring. From January 2000 to June 2011, 297 records were obtained (78 from women and 219 from men). Subjects were 20 to 84 years of age. They resided in Brno, Czech Republic, and were mostly clinically healthy at the time of monitoring. All but 23 records covered a week. Data from the 274 complete records were analyzed by least squares spectrum in the frequency range from 1 cycle per week to 12 cycles per day. Population-mean cosinor spectra were obtained to assess the infradian-to-circadian (frequencies of 1 to 7 cycles per week) and circadian-to-ultradian (frequencies between 1 and 7 cycles per day) spectral domains. With increasing age, the circadian amplitude of blood pressure was reduced and the circadian acrophase of blood pressure was advanced. There was also a transposition of the variance from the circadian to both the infradian and ultradian domains. These results are in keeping with a previous investigation of a less homogeneous population. They provide further evidence for the need to refine reference standards by accounting for changes with age in circadian (and other) rhythm characteristics.

Original languageEnglish (US)
Pages (from-to)141-156
Number of pages16
JournalWorld Heart Journal
Issue number2
StatePublished - Jan 1 2016


  • Aging
  • Blood pressure
  • Circadian
  • Heart rate
  • Infradian
  • Ultradian
  • Variance transposition


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