Changes over 14 years in androgenicity and body mass index in a biracial cohort of reproductive-age women

Barbara Sternfeld, Kiang Liu, Charles P. Quesenberry, Hua Wang, Sheng Fang Jiang, Martha Daviglus, Myriam Fornage, Cora E. Lewis, John Mahan, Pamela J. Schreiner, Stephen M. Schwartz, Stephen Sidney, O. Dale Williams, David S. Siscovick

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Background: Body mass index (BMI) is directly related to testosterone (total T and free T) and inversely to SHBG cross-sectionally, but little is known about how changes in body fat and androgen markers affect each other over time. Methods: Participants included 969 White and Black women from the Coronary Artery Risk Development in Young Adults (CARDIA) cohort, who were ages 18-30 at entry into the study and were pre- or perimenopausal 16 yr later at the time of the CARDIA Women's Study (CWS). Total T and SHBG were assayed from specimens drawn at the CWS examination and stored serum from the yr 2 and 10 CARDIA exams. Free T was calculated based on total T and SHBG. BMI and waist circumference were measured at yr 2, 10, and 16. Results: Despite clinically significant increases in BMI and waist circumference, total T and free T tended to decline, whereas SHBG remained relatively constant. BMI and waist circumference were directly correlated with free T and inversely correlated with SHBG in cross-sectional analyses. In longitudinal, multivariable analyses, an annualized increase in BMI was inversely related to a concurrent annualized decrease in SHBG (β = -0.79 ng/dl, and SE = 0.22 in Blacks; β = -1.07 ng/dl; and SE = 0.31 in Whites). However, early increases in BMI were not related to later decreases in SHBG. Conclusion: Increases in adiposity are closely tied to decreases in SHBG, but changes in BMI and SHBG may occur concurrently rather than sequentially.

Original languageEnglish (US)
Pages (from-to)2158-2165
Number of pages8
JournalJournal of Clinical Endocrinology and Metabolism
Volume93
Issue number6
DOIs
StatePublished - Jun 2008

Bibliographical note

Funding Information:
This research was supported by a grant from the National Heart, Lung, and Blood Institute (R01-HL065611) and contracts N01-HC-48047, N01-HC-48048, N01-HC-48049, and N01-HC-48050.

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