Changes in Vitamin E Concentrations in Human Plasma and Platelets With Age

Govind T. Vatassery, Gerhard J. Johnson, Ann M. Krezowski

Research output: Contribution to journalArticlepeer-review

53 Scopus citations


It has been postulated that vitamin E compounds (tocopherols) can retard the aging process. Therefore, changes in concentrations of tocopherols in human plasma and platelets with aging were studied. Fasting blood samples were obtained from 48 healthy male volunteers aged 24-91 years. Concentrations of the tocopherols in plasma and platelets were determined by a liquid chromatographic method. Alpha and gamma tocopherols were the major forms of vitamin E found in both plasma and platelets. The concentrations of alpha and total tocopherols in plasma did not change significantly with age. However, the plasma gamma tocopherol and the platelet alpha, gamma, and total tocopherol concentrations decreased significantly with age. The platelet to plasma ratios of tocopherol concentrations also decreased with age.

Original languageEnglish (US)
Pages (from-to)369-375
Number of pages7
JournalJournal of the American College of Nutrition
Issue number4
StatePublished - Jan 1 1983

Bibliographical note

Funding Information:
This work was supported by to thank Michael Kuskowski,

Copyright 2015 Elsevier B.V., All rights reserved.


  • Aging
  • Alpha tocopherol
  • Gamma tocopherol
  • Human
  • Plasma
  • Platelets
  • Vitamin E


Dive into the research topics of 'Changes in Vitamin E Concentrations in Human Plasma and Platelets With Age'. Together they form a unique fingerprint.

Cite this