Changes in the affinity of [3H]nimodipine binding sites in the brain upon chlorpromazine treatment and subsequent withdrawal

V. Ramkumar; Esam E El-Fakahany

Changes in the affinity of [³H]nimodipine binding sites in the brain upon chlorpromazine treatment and subsequent withdrawal

V. Ramkumar
, Esam E El-Fakahany

Research output: Contribution to journal › Article › peer-review

Abstract

Male mice were chronically treated with chlorpromazine mixed in powdered diet, and the properties of brain calcium channels were assessed using [³H]nimodipine binding. It was found that this treatment resulted in a significant increase in the affinity of calcium channels, without a significant change in their density. These effects of chlorpromazine were time dependent. When mice were administered chlorpromazine for 2 months, then the drug was withdrawn, there was a rebound decrease in the channel affinity.

Original language	English (US)
Pages (from-to)	463-466
Number of pages	4
Journal	Research Communications in Chemical Pathology and Pharmacology
Volume	48
Issue number	3
State	Published - Jan 1 1985
Externally published	Yes

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title = "Changes in the affinity of [3H]nimodipine binding sites in the brain upon chlorpromazine treatment and subsequent withdrawal",

abstract = "Male mice were chronically treated with chlorpromazine mixed in powdered diet, and the properties of brain calcium channels were assessed using [3H]nimodipine binding. It was found that this treatment resulted in a significant increase in the affinity of calcium channels, without a significant change in their density. These effects of chlorpromazine were time dependent. When mice were administered chlorpromazine for 2 months, then the drug was withdrawn, there was a rebound decrease in the channel affinity.",

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AU - Ramkumar, V.

AU - El-Fakahany, Esam E

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N2 - Male mice were chronically treated with chlorpromazine mixed in powdered diet, and the properties of brain calcium channels were assessed using [3H]nimodipine binding. It was found that this treatment resulted in a significant increase in the affinity of calcium channels, without a significant change in their density. These effects of chlorpromazine were time dependent. When mice were administered chlorpromazine for 2 months, then the drug was withdrawn, there was a rebound decrease in the channel affinity.

AB - Male mice were chronically treated with chlorpromazine mixed in powdered diet, and the properties of brain calcium channels were assessed using [3H]nimodipine binding. It was found that this treatment resulted in a significant increase in the affinity of calcium channels, without a significant change in their density. These effects of chlorpromazine were time dependent. When mice were administered chlorpromazine for 2 months, then the drug was withdrawn, there was a rebound decrease in the channel affinity.

UR - https://www.scopus.com/pages/publications/0021893423

UR - https://www.scopus.com/pages/publications/0021893423#tab=citedBy

M3 - Article

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ER -

Changes in the affinity of [³H]nimodipine binding sites in the brain upon chlorpromazine treatment and subsequent withdrawal

Abstract

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