Changes in the affinity of [3H]nimodipine binding sites in the brain upon chlorpromazine treatment and subsequent withdrawal

V. Ramkumar, Esam E El-Fakahany

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Male mice were chronically treated with chlorpromazine mixed in powdered diet, and the properties of brain calcium channels were assessed using [3H]nimodipine binding. It was found that this treatment resulted in a significant increase in the affinity of calcium channels, without a significant change in their density. These effects of chlorpromazine were time dependent. When mice were administered chlorpromazine for 2 months, then the drug was withdrawn, there was a rebound decrease in the channel affinity.

Original languageEnglish (US)
Pages (from-to)463-466
Number of pages4
JournalResearch Communications in Chemical Pathology and Pharmacology
Volume48
Issue number3
StatePublished - Jan 1 1985
Externally publishedYes

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