Changes in sudomotor nerve territories with aging in the mouse

Xavier Navarro, William R. Kennedy

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


This study evaluates sudomotor function in the hindpaw of young and aged mice. Sweating was stimulated by pilocarpine injection and by electrical stimulation of the sciatic, tibial, peroneal, sural and saphenous nerves. The number of responsive sweat glands of the paw was determined by the silicon mold technique. The results obtained provide evidence that the number of functioning sweat glands of the hindpaw tended to decrease in aged mice. The peripheral sudomotor territories and the complement of sweat glands for individual nerves declined slightly with age. Moreover, the number of sweat glands responsive to cholinergic stimulation was decreased when compared with the number responsive to electrical stimulation of the sciatic nerve in aged mice. These and previous observations suggest that the number of sudomotor axons in the peripheral nerve, as well as their capabilities for compensatory reinnervation of sweat glands by regeneration and by sprouting, is reduced with aging.

Original languageEnglish (US)
Pages (from-to)101-107
Number of pages7
JournalJournal of the Autonomic Nervous System
Issue number2
StatePublished - Nov 1990

Bibliographical note

Funding Information:
This work was partially supported by grants from the C.I.R.I.T., Generalitat de Catalunya (X.N.), and the Minnesota Medical Foundation (W.R.K.).


  • Aging
  • Sudomotor axon
  • Sweat gland
  • peripheral nerve


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