TY - JOUR
T1 - Changes in prefrontal cortex and paralimbic activity in depression following two weeks of daily left prefrontal TMS
AU - Teneback, Charlotte C.
AU - Nahas, Ziad
AU - Speer, Andrew M.
AU - Molloy, Monica
AU - Stallings, Laurie E.
AU - Spicer, Kenneth M.
AU - Risch, S. Craig
AU - George, Mark S.
PY - 1999/9
Y1 - 1999/9
N2 - Twenty-two depressed adults were scanned with perfusion single-photon computed emission tomography before and after 2 weeks of left prefrontal transcranial magnetic stimulation (TMS) in a parallel design, double-blind treatment study. At medication-free baseline, across all subjects, blood flow in the bilateral medial temporal lobes, left prefrontal cortex, and caudate significantly declined with increased depression severity. Also at baseline, depressed adults who responded to TMS, compared with nonresponders, showed increased inferior frontal lobe activity. Following treatment, there was an even greater difference in inferior frontal blood flow in responder compared with nonresponders, and the negative baseline correlations between depression severity and limbic and prefrontal blood flow disappeared. These results suggest that in depressed adults, 10 days of prefrontal TMS affects prefrontal and paralimbic activity, which may explain its antidepressant effects.
AB - Twenty-two depressed adults were scanned with perfusion single-photon computed emission tomography before and after 2 weeks of left prefrontal transcranial magnetic stimulation (TMS) in a parallel design, double-blind treatment study. At medication-free baseline, across all subjects, blood flow in the bilateral medial temporal lobes, left prefrontal cortex, and caudate significantly declined with increased depression severity. Also at baseline, depressed adults who responded to TMS, compared with nonresponders, showed increased inferior frontal lobe activity. Following treatment, there was an even greater difference in inferior frontal blood flow in responder compared with nonresponders, and the negative baseline correlations between depression severity and limbic and prefrontal blood flow disappeared. These results suggest that in depressed adults, 10 days of prefrontal TMS affects prefrontal and paralimbic activity, which may explain its antidepressant effects.
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M3 - Article
C2 - 10570754
AN - SCOPUS:0032721293
SN - 0895-0172
VL - 11
SP - 426
EP - 435
JO - Journal of Neuropsychiatry and Clinical Neurosciences
JF - Journal of Neuropsychiatry and Clinical Neurosciences
IS - 4
ER -