Changes in membrane dynamics associated with myogenic cell fusion

B. A. Herman, S. M. Fernandez

Research output: Contribution to journalArticlepeer-review

46 Scopus citations

Abstract

Changes in membrane dynamic properties associated with membrane fusion are studied employing in vitro myoblast fusion as a model system. We utilize a microscopic fluorescence relaxation approach which makes feasible the study of local variations in membrane dynamics within surface subdomains of single intact cells. Studies of the average rotational mobility of the fluorescent probe‐1‐anilino‐naphthalene‐8‐sulfonate by this technique indicate that myoblast fusion activity is preceded by a generalized increased in membrane fluidity and that areas of cell contact between fusing cells exhibit higher fluidity and polarity, locally, than non‐fusion regions.

Original languageEnglish (US)
Pages (from-to)253-263
Number of pages11
JournalJournal of Cellular Physiology
Volume94
Issue number3
DOIs
StatePublished - Mar 1978

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