Changes in inflammation, oxidative stress and adipokines following bariatric surgery among adolescents with severe obesity

Aaron S Kelly, Justin R Ryder, K. L. Marlatt, Kyle Rudser, T. Jenkins, T. H. Inge

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Abstract

Inflammation, oxidative stress and dysregulation of adipokines are thought to be pathophysiological mechanisms linking obesity to the development of insulin resistance and atherosclerosis. In adults, bariatric surgery reduces inflammation and oxidative stress, and beneficially changes the levels of several adipokines, but little is known about the postsurgical changes among adolescents.Subjects/Methods:In two separate longitudinal cohorts we evaluated change from baseline of interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), monocyte chemo-attractant protein-1 (MCP-1), oxidized low-density lipoprotein cholesterol (oxLDL), adiponectin, leptin and resistin up to 12 months following elective laparoscopic Roux-en-Y gastric bypass (RYGB) or vertical sleeve gastrectomy (VSG) surgery in adolescents with severe obesity.Results:In cohort 1, which consisted of 39 adolescents (mean age 16.5±1.6 years; 29 females) undergoing either RYGB or VSG, IL-6 (baseline: 2.3±3.4 pg ml-1 vs 12 months: 0.8±0.6 pg ml-1, P<0.01), leptin (baseline: 178±224 ng ml-1 vs 12 months: 41.4±31.9 ng ml-1, P<0.001) and oxLDL (baseline: 41.6±11.6 Ul-1 vs 12 months: 35.5±11.1 Ul-1, P=0.001) significantly decreased and adiponectin significantly increased (baseline: 5.4±2.4 μg ml-1 vs 12 months: 13.5±8.9 μg ml-1, P<0.001). In cohort 2, which consisted of 13 adolescents (mean age 16.5±1.6 years; 10 females) undergoing RYGB, results were similar: IL-6 (baseline: 1.7±0.9 pg ml-1 vs 12 months: 0.4±0.9 pg ml-1, P<0.05) and leptin (baseline: 92.9±31.3 ng ml-1 vs 12 months: 37.3±33.4 ng ml-1, P<0.001) significantly decreased and adiponectin significantly increased (baseline: 6.1±2.9 μg ml-1 vs 12 months: 15.4±8.0 μg ml-1, P<0.001). When the cohorts were combined to evaluate changes at 12 months, oxLDL also significantly decreased (baseline: 39.8±16.7 Ul-1 vs 12 months: 32.7±11.9 Ul-1, P=0.03).Conclusions:Bariatric surgery produced robust improvements in markers of inflammation, oxidative stress and several adipokines among adolescents with severe obesity, suggesting potential reductions in risk for type 2 diabetes and cardiovascular disease.

Original languageEnglish (US)
Pages (from-to)275-280
Number of pages6
JournalInternational Journal of Obesity
Volume40
Issue number2
DOIs
StatePublished - Feb 1 2016

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Adipokines
Bariatric Surgery
Morbid Obesity
Oxidative Stress
Gastric Bypass
Inflammation
Adiponectin
Leptin
LDL Cholesterol
Interleukin-6
Gastrectomy
Resistin
Risk Reduction Behavior
Type 2 Diabetes Mellitus
Insulin Resistance
Monocytes
Atherosclerosis
Cardiovascular Diseases
Tumor Necrosis Factor-alpha
Obesity

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Changes in inflammation, oxidative stress and adipokines following bariatric surgery among adolescents with severe obesity. / Kelly, Aaron S; Ryder, Justin R; Marlatt, K. L.; Rudser, Kyle; Jenkins, T.; Inge, T. H.

In: International Journal of Obesity, Vol. 40, No. 2, 01.02.2016, p. 275-280.

Research output: Contribution to journalArticle

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abstract = "Inflammation, oxidative stress and dysregulation of adipokines are thought to be pathophysiological mechanisms linking obesity to the development of insulin resistance and atherosclerosis. In adults, bariatric surgery reduces inflammation and oxidative stress, and beneficially changes the levels of several adipokines, but little is known about the postsurgical changes among adolescents.Subjects/Methods:In two separate longitudinal cohorts we evaluated change from baseline of interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), monocyte chemo-attractant protein-1 (MCP-1), oxidized low-density lipoprotein cholesterol (oxLDL), adiponectin, leptin and resistin up to 12 months following elective laparoscopic Roux-en-Y gastric bypass (RYGB) or vertical sleeve gastrectomy (VSG) surgery in adolescents with severe obesity.Results:In cohort 1, which consisted of 39 adolescents (mean age 16.5±1.6 years; 29 females) undergoing either RYGB or VSG, IL-6 (baseline: 2.3±3.4 pg ml-1 vs 12 months: 0.8±0.6 pg ml-1, P<0.01), leptin (baseline: 178±224 ng ml-1 vs 12 months: 41.4±31.9 ng ml-1, P<0.001) and oxLDL (baseline: 41.6±11.6 Ul-1 vs 12 months: 35.5±11.1 Ul-1, P=0.001) significantly decreased and adiponectin significantly increased (baseline: 5.4±2.4 μg ml-1 vs 12 months: 13.5±8.9 μg ml-1, P<0.001). In cohort 2, which consisted of 13 adolescents (mean age 16.5±1.6 years; 10 females) undergoing RYGB, results were similar: IL-6 (baseline: 1.7±0.9 pg ml-1 vs 12 months: 0.4±0.9 pg ml-1, P<0.05) and leptin (baseline: 92.9±31.3 ng ml-1 vs 12 months: 37.3±33.4 ng ml-1, P<0.001) significantly decreased and adiponectin significantly increased (baseline: 6.1±2.9 μg ml-1 vs 12 months: 15.4±8.0 μg ml-1, P<0.001). When the cohorts were combined to evaluate changes at 12 months, oxLDL also significantly decreased (baseline: 39.8±16.7 Ul-1 vs 12 months: 32.7±11.9 Ul-1, P=0.03).Conclusions:Bariatric surgery produced robust improvements in markers of inflammation, oxidative stress and several adipokines among adolescents with severe obesity, suggesting potential reductions in risk for type 2 diabetes and cardiovascular disease.",
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T1 - Changes in inflammation, oxidative stress and adipokines following bariatric surgery among adolescents with severe obesity

AU - Kelly, Aaron S

AU - Ryder, Justin R

AU - Marlatt, K. L.

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AU - Jenkins, T.

AU - Inge, T. H.

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N2 - Inflammation, oxidative stress and dysregulation of adipokines are thought to be pathophysiological mechanisms linking obesity to the development of insulin resistance and atherosclerosis. In adults, bariatric surgery reduces inflammation and oxidative stress, and beneficially changes the levels of several adipokines, but little is known about the postsurgical changes among adolescents.Subjects/Methods:In two separate longitudinal cohorts we evaluated change from baseline of interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), monocyte chemo-attractant protein-1 (MCP-1), oxidized low-density lipoprotein cholesterol (oxLDL), adiponectin, leptin and resistin up to 12 months following elective laparoscopic Roux-en-Y gastric bypass (RYGB) or vertical sleeve gastrectomy (VSG) surgery in adolescents with severe obesity.Results:In cohort 1, which consisted of 39 adolescents (mean age 16.5±1.6 years; 29 females) undergoing either RYGB or VSG, IL-6 (baseline: 2.3±3.4 pg ml-1 vs 12 months: 0.8±0.6 pg ml-1, P<0.01), leptin (baseline: 178±224 ng ml-1 vs 12 months: 41.4±31.9 ng ml-1, P<0.001) and oxLDL (baseline: 41.6±11.6 Ul-1 vs 12 months: 35.5±11.1 Ul-1, P=0.001) significantly decreased and adiponectin significantly increased (baseline: 5.4±2.4 μg ml-1 vs 12 months: 13.5±8.9 μg ml-1, P<0.001). In cohort 2, which consisted of 13 adolescents (mean age 16.5±1.6 years; 10 females) undergoing RYGB, results were similar: IL-6 (baseline: 1.7±0.9 pg ml-1 vs 12 months: 0.4±0.9 pg ml-1, P<0.05) and leptin (baseline: 92.9±31.3 ng ml-1 vs 12 months: 37.3±33.4 ng ml-1, P<0.001) significantly decreased and adiponectin significantly increased (baseline: 6.1±2.9 μg ml-1 vs 12 months: 15.4±8.0 μg ml-1, P<0.001). When the cohorts were combined to evaluate changes at 12 months, oxLDL also significantly decreased (baseline: 39.8±16.7 Ul-1 vs 12 months: 32.7±11.9 Ul-1, P=0.03).Conclusions:Bariatric surgery produced robust improvements in markers of inflammation, oxidative stress and several adipokines among adolescents with severe obesity, suggesting potential reductions in risk for type 2 diabetes and cardiovascular disease.

AB - Inflammation, oxidative stress and dysregulation of adipokines are thought to be pathophysiological mechanisms linking obesity to the development of insulin resistance and atherosclerosis. In adults, bariatric surgery reduces inflammation and oxidative stress, and beneficially changes the levels of several adipokines, but little is known about the postsurgical changes among adolescents.Subjects/Methods:In two separate longitudinal cohorts we evaluated change from baseline of interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), monocyte chemo-attractant protein-1 (MCP-1), oxidized low-density lipoprotein cholesterol (oxLDL), adiponectin, leptin and resistin up to 12 months following elective laparoscopic Roux-en-Y gastric bypass (RYGB) or vertical sleeve gastrectomy (VSG) surgery in adolescents with severe obesity.Results:In cohort 1, which consisted of 39 adolescents (mean age 16.5±1.6 years; 29 females) undergoing either RYGB or VSG, IL-6 (baseline: 2.3±3.4 pg ml-1 vs 12 months: 0.8±0.6 pg ml-1, P<0.01), leptin (baseline: 178±224 ng ml-1 vs 12 months: 41.4±31.9 ng ml-1, P<0.001) and oxLDL (baseline: 41.6±11.6 Ul-1 vs 12 months: 35.5±11.1 Ul-1, P=0.001) significantly decreased and adiponectin significantly increased (baseline: 5.4±2.4 μg ml-1 vs 12 months: 13.5±8.9 μg ml-1, P<0.001). In cohort 2, which consisted of 13 adolescents (mean age 16.5±1.6 years; 10 females) undergoing RYGB, results were similar: IL-6 (baseline: 1.7±0.9 pg ml-1 vs 12 months: 0.4±0.9 pg ml-1, P<0.05) and leptin (baseline: 92.9±31.3 ng ml-1 vs 12 months: 37.3±33.4 ng ml-1, P<0.001) significantly decreased and adiponectin significantly increased (baseline: 6.1±2.9 μg ml-1 vs 12 months: 15.4±8.0 μg ml-1, P<0.001). When the cohorts were combined to evaluate changes at 12 months, oxLDL also significantly decreased (baseline: 39.8±16.7 Ul-1 vs 12 months: 32.7±11.9 Ul-1, P=0.03).Conclusions:Bariatric surgery produced robust improvements in markers of inflammation, oxidative stress and several adipokines among adolescents with severe obesity, suggesting potential reductions in risk for type 2 diabetes and cardiovascular disease.

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