SARS-CoV-2 has spread rapidly worldwide, but the full impact of the COVID-19 pandemic on the field of hematopoietic cell transplantation (HCT) remains unknown. To understand this better, an 18-item online survey was disseminated by the Worldwide Network for Blood & Marrow Transplantation with questions exploring SARS-CoV-2 testing algorithms, mobilization, and cryopreservation strategies and COVID-19 infections in allogeneic related and autologous hematopoietic progenitor cell (HPC) donors. The aim of this survey was to assess the impact of the outbreak on policies relating to HPC mobilization, collection, and processing with respect to changes in daily routine. A total of 91 individual responses from distinct centers in 6 continents were available for analysis. In these centers, the majority (72%) of allogeneic related and autologous donors are routinely tested for SARS-CoV-2 before HPC collection, and 80% of centers implement cryopreservation of allogeneic HPC grafts before commencing conditioning regimens in patients. Five related and 14 autologous donors who tested positive for COVID-19 did not experience any unexpected adverse events or reactions during growth factor administration (eg, hyperinflammatory syndrome). These data are limited by the small number of survey respondents but nonetheless suggest that centers are following the recommendations of appropriate scientific organizations and provide some preliminary data to suggest areas of further study.
|Original language||English (US)|
|Journal||Transplantation and Cellular Therapy|
|State||Published - Mar 1 2021|
Bibliographical noteFunding Information:
The authors thank Martine Schuit for translating the questionnaire into the SurveyGizmo tool and distributing the link. The authors are grateful to all centers who participated and thank all staff members at the various institutions for their support. Financial disclosure: There are no financial dislosures to report in the context of the submitted manuscrip. Conflict of interest statement: There are no conflicts of interest to report. Authorship statement: N.W. B.S. M.A. M.K. A.S. D.W. J.S. S.G. Y.K. P.E. S.H. Y.A. J.S. W.S. D.N. and H.G. designed the survey and wrote the manuscript, and N.W. analyzed the data.
© 2020 The American Society for Transplantation and Cellular Therapy