Changes in food-maintained progressive-ratio responding of rats following chronic buprenorphine or methadone administration

Mitchell J. Macenski, David W. Schaal, James Cleary, Travis Thompson

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Seven rats lever pressed under a progressive ratio 3 (PR 3) schedule of food presentation; the number of responses per reinforcer systematically increased during each session. Break point (i.e., the number of responses in the last completed ratio before session termination) was measured under daily methadone (4.5 mg/kg and 3.0 mg/kg) or buprenorphine (0.3 mg/kg) administered prior to experimental sessions. Both drugs initially eliminated rats' food-maintained progressive-ratio responding. Break points during chronic methadone did not return to baseline levels after 80 drug sessions and a dose reduction. In contrast, break points during chronic buprenorphine administration were considerably above baseline control levels for two rats and returned to baseline levels for the third.

Original languageEnglish (US)
Pages (from-to)379-383
Number of pages5
JournalPharmacology, Biochemistry and Behavior
Volume47
Issue number2
DOIs
StatePublished - Feb 1994

Keywords

  • Buprenorphine
  • Chronic opioid
  • Food reinforcement
  • Methadone
  • Progressive ratio
  • Rats
  • Tolerance

Fingerprint

Dive into the research topics of 'Changes in food-maintained progressive-ratio responding of rats following chronic buprenorphine or methadone administration'. Together they form a unique fingerprint.

Cite this