Changes in emotion processing and social cognition with auditory versus visual neuroscience-informed cognitive training in individuals with schizophrenia

Linda Scoriels; Larissa T. Genaro; Stella Keffer; Anna Luiza Guimarães; Bárbara Barros-Dumas; Luana G. Mororó; Thales Biagioni; Camila Lucena; Thaís R. da Hora; Barbara J. Sahakian; Melissa Fisher; Sophia Vinogradov; Rogério Panizzutti

doi:10.1016/j.schres.2022.02.013

Changes in emotion processing and social cognition with auditory versus visual neuroscience-informed cognitive training in individuals with schizophrenia

Linda Scoriels, Larissa T. Genaro, Stella Keffer, Anna Luiza Guimarães, Bárbara Barros-Dumas, Luana G. Mororó, Thales Biagioni, Camila Lucena, Thaís R. da Hora, Barbara J. Sahakian, Melissa Fisher, Sophia Vinogradov, Rogério Panizzutti

Psychiatry & Behavioral Sciences

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Background: Neuroscience-informed cognitive training has been used to remediate cognitive deficits in schizophrenia, but their effect on emotion processing and social cognition deficits, which may involve auditory and visual impairments, remain relatively unknown. In this study, we compared the efficacy of auditory versus visual neuroscience-informed cognitive training on emotion processing and social cognition in individuals with schizophrenia. Methods: In this randomised, double-blind clinical trial, 79 participants with chronic schizophrenia performed 40-hours auditory or visual dynamically equivalent computerised cognitive training. We assessed emotion processing and social cognition using Emotion Recognition, Affective Go-NoGo, Mayer-Salovey-Caruso Emotional-Intelligence, Theory of mind, and Hinting tests before and after 20 h and 40 h of training. Results: After training, participants from both groups decreased their reaction time for facial emotion recognition (p = 3 × 10⁻⁶, d = 0.9). This was more remarkable for the auditory group when analysing individual emotions. Both groups also reduced omissions in the affective go-no go (p = 0.01, d = 0.6), which was also attributed, post hoc, to the auditory group. Trends for improvement were observed in theory of mind (p = 0.06, d = 0.6) for both groups. Improvement in emotion processing was associated with improvement in reasoning and problem solving and global cognition and improvement in theory of mind was associated with improvement in attention and global cognition. Conclusions: Both the auditory and the visual neuroscience-informed cognitive training were efficacious at improving emotion processing and social cognition in individuals with schizophrenia, although improvement was more remarkable for the auditory training group. These improvements were related to cognitive – but not symptom – improvement.

Original language	English (US)
Pages (from-to)	267-274
Number of pages	8
Journal	Schizophrenia Research
Volume	241
DOIs	https://doi.org/10.1016/j.schres.2022.02.013
State	Published - Mar 2022

Bibliographical note

Funding Information:
This work was supported by the National Institutes of Health – Fogarty International Center (Grant R03TW009002 ) to RP and SV; Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ) (Grant E-26/110.305/2014 ) and Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) (Grant 400455/2012-9 ). RP is an Atlantic Fellow of the Global Brain Health Institute . BJK research is conducted within the NIHR MedTech and Invitro Diagnostic Co-operative (MIC) and the NIHR Cambridge Biomedical Research Centre (Neurodegeneration and Mental Health Themes). LS, LTG, SK, ALG, BBD, LGM, TB, CL, JO, and TRH were supported by fellowships from FAPERJ and CNPq .

Publisher Copyright:
© 2022 Elsevier B.V.

Keywords

Auditory training
Emotion processing
Neuroscience-informed
Schizophrenia
Social cognition
Visual training

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10.1016/j.schres.2022.02.013

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Scoriels, L., Genaro, L. T., Keffer, S., Guimarães, A. L., Barros-Dumas, B., Mororó, L. G., Biagioni, T., Lucena, C., da Hora, T. R., Sahakian, B. J., Fisher, M., Vinogradov, S., & Panizzutti, R. (2022). Changes in emotion processing and social cognition with auditory versus visual neuroscience-informed cognitive training in individuals with schizophrenia. Schizophrenia Research, 241, 267-274. https://doi.org/10.1016/j.schres.2022.02.013

Scoriels, L, Genaro, LT, Keffer, S, Guimarães, AL, Barros-Dumas, B, Mororó, LG, Biagioni, T, Lucena, C, da Hora, TR, Sahakian, BJ, Fisher, M , Vinogradov, S & Panizzutti, R 2022, 'Changes in emotion processing and social cognition with auditory versus visual neuroscience-informed cognitive training in individuals with schizophrenia', Schizophrenia Research, vol. 241, pp. 267-274. https://doi.org/10.1016/j.schres.2022.02.013

@article{90c0cb141fdc4147a749e17973ba0131,

title = "Changes in emotion processing and social cognition with auditory versus visual neuroscience-informed cognitive training in individuals with schizophrenia",

abstract = "Background: Neuroscience-informed cognitive training has been used to remediate cognitive deficits in schizophrenia, but their effect on emotion processing and social cognition deficits, which may involve auditory and visual impairments, remain relatively unknown. In this study, we compared the efficacy of auditory versus visual neuroscience-informed cognitive training on emotion processing and social cognition in individuals with schizophrenia. Methods: In this randomised, double-blind clinical trial, 79 participants with chronic schizophrenia performed 40-hours auditory or visual dynamically equivalent computerised cognitive training. We assessed emotion processing and social cognition using Emotion Recognition, Affective Go-NoGo, Mayer-Salovey-Caruso Emotional-Intelligence, Theory of mind, and Hinting tests before and after 20 h and 40 h of training. Results: After training, participants from both groups decreased their reaction time for facial emotion recognition (p = 3 × 10−6, d = 0.9). This was more remarkable for the auditory group when analysing individual emotions. Both groups also reduced omissions in the affective go-no go (p = 0.01, d = 0.6), which was also attributed, post hoc, to the auditory group. Trends for improvement were observed in theory of mind (p = 0.06, d = 0.6) for both groups. Improvement in emotion processing was associated with improvement in reasoning and problem solving and global cognition and improvement in theory of mind was associated with improvement in attention and global cognition. Conclusions: Both the auditory and the visual neuroscience-informed cognitive training were efficacious at improving emotion processing and social cognition in individuals with schizophrenia, although improvement was more remarkable for the auditory training group. These improvements were related to cognitive – but not symptom – improvement.",

keywords = "Auditory training, Emotion processing, Neuroscience-informed, Schizophrenia, Social cognition, Visual training",

author = "Linda Scoriels and Genaro, {Larissa T.} and Stella Keffer and Guimar{\~a}es, {Anna Luiza} and B{\'a}rbara Barros-Dumas and Moror{\'o}, {Luana G.} and Thales Biagioni and Camila Lucena and {da Hora}, {Tha{\'i}s R.} and Sahakian, {Barbara J.} and Melissa Fisher and Sophia Vinogradov and Rog{\'e}rio Panizzutti",

note = "Funding Information: This work was supported by the National Institutes of Health – Fogarty International Center (Grant R03TW009002 ) to RP and SV; Funda{\c c}{\~a}o de Amparo {\`a} Pesquisa do Estado do Rio de Janeiro (FAPERJ) (Grant E-26/110.305/2014 ) and Conselho Nacional de Desenvolvimento Cient{\'i}fico e Tecnol{\'o}gico (CNPq) (Grant 400455/2012-9 ). RP is an Atlantic Fellow of the Global Brain Health Institute . BJK research is conducted within the NIHR MedTech and Invitro Diagnostic Co-operative (MIC) and the NIHR Cambridge Biomedical Research Centre (Neurodegeneration and Mental Health Themes). LS, LTG, SK, ALG, BBD, LGM, TB, CL, JO, and TRH were supported by fellowships from FAPERJ and CNPq . Publisher Copyright: {\textcopyright} 2022 Elsevier B.V.",

year = "2022",

month = mar,

doi = "10.1016/j.schres.2022.02.013",

language = "English (US)",

volume = "241",

pages = "267--274",

journal = "Schizophrenia Research",

issn = "0920-9964",

publisher = "Elsevier B.V.",

}

TY - JOUR

T1 - Changes in emotion processing and social cognition with auditory versus visual neuroscience-informed cognitive training in individuals with schizophrenia

AU - Scoriels, Linda

AU - Genaro, Larissa T.

AU - Keffer, Stella

AU - Guimarães, Anna Luiza

AU - Barros-Dumas, Bárbara

AU - Mororó, Luana G.

AU - Biagioni, Thales

AU - Lucena, Camila

AU - da Hora, Thaís R.

AU - Sahakian, Barbara J.

AU - Fisher, Melissa

AU - Vinogradov, Sophia

AU - Panizzutti, Rogério

N1 - Funding Information: This work was supported by the National Institutes of Health – Fogarty International Center (Grant R03TW009002 ) to RP and SV; Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ) (Grant E-26/110.305/2014 ) and Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) (Grant 400455/2012-9 ). RP is an Atlantic Fellow of the Global Brain Health Institute . BJK research is conducted within the NIHR MedTech and Invitro Diagnostic Co-operative (MIC) and the NIHR Cambridge Biomedical Research Centre (Neurodegeneration and Mental Health Themes). LS, LTG, SK, ALG, BBD, LGM, TB, CL, JO, and TRH were supported by fellowships from FAPERJ and CNPq . Publisher Copyright: © 2022 Elsevier B.V.

PY - 2022/3

Y1 - 2022/3

N2 - Background: Neuroscience-informed cognitive training has been used to remediate cognitive deficits in schizophrenia, but their effect on emotion processing and social cognition deficits, which may involve auditory and visual impairments, remain relatively unknown. In this study, we compared the efficacy of auditory versus visual neuroscience-informed cognitive training on emotion processing and social cognition in individuals with schizophrenia. Methods: In this randomised, double-blind clinical trial, 79 participants with chronic schizophrenia performed 40-hours auditory or visual dynamically equivalent computerised cognitive training. We assessed emotion processing and social cognition using Emotion Recognition, Affective Go-NoGo, Mayer-Salovey-Caruso Emotional-Intelligence, Theory of mind, and Hinting tests before and after 20 h and 40 h of training. Results: After training, participants from both groups decreased their reaction time for facial emotion recognition (p = 3 × 10−6, d = 0.9). This was more remarkable for the auditory group when analysing individual emotions. Both groups also reduced omissions in the affective go-no go (p = 0.01, d = 0.6), which was also attributed, post hoc, to the auditory group. Trends for improvement were observed in theory of mind (p = 0.06, d = 0.6) for both groups. Improvement in emotion processing was associated with improvement in reasoning and problem solving and global cognition and improvement in theory of mind was associated with improvement in attention and global cognition. Conclusions: Both the auditory and the visual neuroscience-informed cognitive training were efficacious at improving emotion processing and social cognition in individuals with schizophrenia, although improvement was more remarkable for the auditory training group. These improvements were related to cognitive – but not symptom – improvement.

AB - Background: Neuroscience-informed cognitive training has been used to remediate cognitive deficits in schizophrenia, but their effect on emotion processing and social cognition deficits, which may involve auditory and visual impairments, remain relatively unknown. In this study, we compared the efficacy of auditory versus visual neuroscience-informed cognitive training on emotion processing and social cognition in individuals with schizophrenia. Methods: In this randomised, double-blind clinical trial, 79 participants with chronic schizophrenia performed 40-hours auditory or visual dynamically equivalent computerised cognitive training. We assessed emotion processing and social cognition using Emotion Recognition, Affective Go-NoGo, Mayer-Salovey-Caruso Emotional-Intelligence, Theory of mind, and Hinting tests before and after 20 h and 40 h of training. Results: After training, participants from both groups decreased their reaction time for facial emotion recognition (p = 3 × 10−6, d = 0.9). This was more remarkable for the auditory group when analysing individual emotions. Both groups also reduced omissions in the affective go-no go (p = 0.01, d = 0.6), which was also attributed, post hoc, to the auditory group. Trends for improvement were observed in theory of mind (p = 0.06, d = 0.6) for both groups. Improvement in emotion processing was associated with improvement in reasoning and problem solving and global cognition and improvement in theory of mind was associated with improvement in attention and global cognition. Conclusions: Both the auditory and the visual neuroscience-informed cognitive training were efficacious at improving emotion processing and social cognition in individuals with schizophrenia, although improvement was more remarkable for the auditory training group. These improvements were related to cognitive – but not symptom – improvement.

KW - Auditory training

KW - Emotion processing

KW - Neuroscience-informed

KW - Schizophrenia

KW - Social cognition

KW - Visual training

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DO - 10.1016/j.schres.2022.02.013

M3 - Article

C2 - 35182906

AN - SCOPUS:85124588743

SN - 0920-9964

VL - 241

SP - 267

EP - 274

JO - Schizophrenia Research

JF - Schizophrenia Research

ER -

Changes in emotion processing and social cognition with auditory versus visual neuroscience-informed cognitive training in individuals with schizophrenia

Abstract

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