Changes in Blood Pressure During Young Adulthood and Subsequent Kidney Function Decline

Findings From the Coronary Artery Risk Development in Young Adulthood (CARDIA) Study

Elaine Ku, Eric Vittinghoff, David R Jacobs Jr, Cora E. Lewis, Norrina B. Allen, Kirsten Bibbins-Domingo, Michael Shlipak, Holly Kramer, Carmen A. Peralta

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: Many studies have focused on the association between a single blood pressure (BP) measurement and risk for adverse outcomes. However, the association of BP trajectories during young adulthood with subsequent decline in kidney function has not been well defined. Study Design: Observational cohort study. Setting & Participants: 3,429 participants in the Coronary Artery Risk Development in Young Adulthood (CARDIA) Study enrolled between the ages of 18 and 30 years. Predictors: BP slope during the first 10 years of participation in CARDIA, derived from linear mixed models incorporating all repeated BP measures. Outcome: Decline in estimated glomerular filtration rate (eGFR) during the interval between years 10 and 20 of CARDIA participation using cystatin C measured at years 10, 15, and 20. Results: Mean age of CARDIA participants at year 0 was 25.1 years, 56% were women, and 53% were white. Every 10–mm Hg higher level of systolic (SBP) and diastolic BP (DBP) in year 10 was associated with change in eGFR of −0.09 (95% CI, −0.13 to −0.06) and −0.07 (95% CI, −0.12 to −0.03) mL/min/1.73 m2 per year, respectively. Every 10–mm Hg increase in SBP slope between years 0 and 10 was associated with a subsequent −0.52 (95% CI, −1.02 to −0.03) mL/min/1.73 m2 per year change in kidney function after adjustment for comorbid conditions and SBP at year 10. Similarly, every 10–mm Hg increase in DBP slope between years 0 and 10 was associated with a subsequent change in kidney function of −0.65 (95% CI, −1.23 to −0.07) mL/min/1.73 m2 per year, after adjustment for comorbid conditions and DBP in year 10. Limitations: Observational design. Conclusions: During young adulthood, increasing SBP and DBP are associated with a higher rate of subsequent kidney function decline, independent of BP measured at the beginning of eGFR assessment.

Original languageEnglish (US)
Pages (from-to)243-250
Number of pages8
JournalAmerican Journal of Kidney Diseases
Volume72
Issue number2
DOIs
StatePublished - Aug 1 2018

Fingerprint

Coronary Vessels
Blood Pressure
Kidney
Glomerular Filtration Rate
Cystatin C
Observational Studies
Linear Models
Cohort Studies

Keywords

  • BP slope
  • Blood pressure
  • DBP
  • SBP
  • eGFR trajectory
  • estimated glomerular filtration rate (eGFR)
  • hypertension
  • kidney function
  • modifiable risk factor
  • renal outcome
  • young adulthood

PubMed: MeSH publication types

  • Journal Article
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

Cite this

Changes in Blood Pressure During Young Adulthood and Subsequent Kidney Function Decline : Findings From the Coronary Artery Risk Development in Young Adulthood (CARDIA) Study. / Ku, Elaine; Vittinghoff, Eric; Jacobs Jr, David R; Lewis, Cora E.; Allen, Norrina B.; Bibbins-Domingo, Kirsten; Shlipak, Michael; Kramer, Holly; Peralta, Carmen A.

In: American Journal of Kidney Diseases, Vol. 72, No. 2, 01.08.2018, p. 243-250.

Research output: Contribution to journalArticle

Ku, Elaine ; Vittinghoff, Eric ; Jacobs Jr, David R ; Lewis, Cora E. ; Allen, Norrina B. ; Bibbins-Domingo, Kirsten ; Shlipak, Michael ; Kramer, Holly ; Peralta, Carmen A. / Changes in Blood Pressure During Young Adulthood and Subsequent Kidney Function Decline : Findings From the Coronary Artery Risk Development in Young Adulthood (CARDIA) Study. In: American Journal of Kidney Diseases. 2018 ; Vol. 72, No. 2. pp. 243-250.
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abstract = "Background: Many studies have focused on the association between a single blood pressure (BP) measurement and risk for adverse outcomes. However, the association of BP trajectories during young adulthood with subsequent decline in kidney function has not been well defined. Study Design: Observational cohort study. Setting & Participants: 3,429 participants in the Coronary Artery Risk Development in Young Adulthood (CARDIA) Study enrolled between the ages of 18 and 30 years. Predictors: BP slope during the first 10 years of participation in CARDIA, derived from linear mixed models incorporating all repeated BP measures. Outcome: Decline in estimated glomerular filtration rate (eGFR) during the interval between years 10 and 20 of CARDIA participation using cystatin C measured at years 10, 15, and 20. Results: Mean age of CARDIA participants at year 0 was 25.1 years, 56{\%} were women, and 53{\%} were white. Every 10–mm Hg higher level of systolic (SBP) and diastolic BP (DBP) in year 10 was associated with change in eGFR of −0.09 (95{\%} CI, −0.13 to −0.06) and −0.07 (95{\%} CI, −0.12 to −0.03) mL/min/1.73 m2 per year, respectively. Every 10–mm Hg increase in SBP slope between years 0 and 10 was associated with a subsequent −0.52 (95{\%} CI, −1.02 to −0.03) mL/min/1.73 m2 per year change in kidney function after adjustment for comorbid conditions and SBP at year 10. Similarly, every 10–mm Hg increase in DBP slope between years 0 and 10 was associated with a subsequent change in kidney function of −0.65 (95{\%} CI, −1.23 to −0.07) mL/min/1.73 m2 per year, after adjustment for comorbid conditions and DBP in year 10. Limitations: Observational design. Conclusions: During young adulthood, increasing SBP and DBP are associated with a higher rate of subsequent kidney function decline, independent of BP measured at the beginning of eGFR assessment.",
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AU - Jacobs Jr, David R

AU - Lewis, Cora E.

AU - Allen, Norrina B.

AU - Bibbins-Domingo, Kirsten

AU - Shlipak, Michael

AU - Kramer, Holly

AU - Peralta, Carmen A.

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