Challenges to research and innovation to optimize deceased donor organ quality and quantity

P. L. Abt, C. L. Marsh, T. B. Dunn, W. R. Hewitt, J. R. Rodrigue, J. M. Ham, S. Feng

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

Solid organ transplantation is encumbered by an increasing number of waitlisted patients unrequited by the current organ supply. Preclinical models suggest that advances in deceased donor management and treatment can increase the quantity and quality of organs available for transplantation. However, the science of donor intervention and the execution of high quality, prospective, multi-center, randomized-controlled trials are restricted by a myriad of logistical challenges mired in regulatory and ethical ambiguity. By highlighting the obstacles to conducting research in deceased donors, this report endeavors to stimulate the creation of a multi-disciplinary framework to facilitate the design, implementation and supervision of innovative trials that increase the quantity and/or quality of deceased donor organs. This report is a collaborative effort to identify and highlight some of the ethical, logistical, and regulatory ambiguities that impede the development, design, and implementation of innovative trials relevant to deceased donor organ donation.

Original languageEnglish (US)
Pages (from-to)1400-1404
Number of pages5
JournalAmerican Journal of Transplantation
Volume13
Issue number6
DOIs
StatePublished - Jun 2013

Keywords

  • Consent
  • deceased donor
  • donor management research
  • kidney transplantation
  • liver transplantation
  • next-of-kin

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    Abt, P. L., Marsh, C. L., Dunn, T. B., Hewitt, W. R., Rodrigue, J. R., Ham, J. M., & Feng, S. (2013). Challenges to research and innovation to optimize deceased donor organ quality and quantity. American Journal of Transplantation, 13(6), 1400-1404. https://doi.org/10.1111/ajt.12243