Challenges in conducting clinical trials in nephrology: conclusions from a Kidney Disease—Improving Global Outcomes (KDIGO) Controversies Conference

KDIGO Controversies Conference on Challenges in the Conduct of Clinical Trials in Nephrology Conference Participants, KDIGO Controversies Conference on Challenges in the Conduct of Clinical Trials in Nephrology Conference Participants

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Abstract

Despite the high costs of treatment of people with kidney disease and associated comorbid conditions, the amount of reliable information available to guide the care of such patients is very limited. Some treatments have been assessed in randomized trials, but most such trials have been too small to detect treatment effects of a magnitude that would be realistic to achieve with a single intervention. Therefore, KDIGO convened an international, multidisciplinary controversies conference titled “Challenges in the Conduct of Clinical Trials in Nephrology” to identify the key barriers to conducting trials in patients with kidney disease. The conference began with plenary talks focusing on the key areas of discussion that included appropriate trial design (covering identification and evaluation of kidney and nonkidney disease outcomes) and sensible trial execution (with particular emphasis on streamlining both design and conduct). Break out group discussions followed in which the key areas of agreement and remaining controversy were identified. Here we summarize the main findings from the conference and set out a range of potential solutions. If followed, these solutions could ensure future trials among people with kidney disease are sufficiently robust to provide reliable answers and are not constrained by inappropriate complexities in design or conduct.

Original languageEnglish (US)
Pages (from-to)297-305
Number of pages9
JournalKidney international
Volume92
Issue number2
DOIs
StatePublished - Aug 2017

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Nephrology
Kidney Diseases
Clinical Trials
Kidney
Health Care Costs
Patient Care
Therapeutics

Keywords

  • kidney disease
  • randomized clinical trials
  • trial conduct
  • trial design

Cite this

KDIGO Controversies Conference on Challenges in the Conduct of Clinical Trials in Nephrology Conference Participants, & KDIGO Controversies Conference on Challenges in the Conduct of Clinical Trials in Nephrology Conference Participants (2017). Challenges in conducting clinical trials in nephrology: conclusions from a Kidney Disease—Improving Global Outcomes (KDIGO) Controversies Conference. Kidney international, 92(2), 297-305. https://doi.org/10.1016/j.kint.2017.04.019

Challenges in conducting clinical trials in nephrology : conclusions from a Kidney Disease—Improving Global Outcomes (KDIGO) Controversies Conference. / KDIGO Controversies Conference on Challenges in the Conduct of Clinical Trials in Nephrology Conference Participants; KDIGO Controversies Conference on Challenges in the Conduct of Clinical Trials in Nephrology Conference Participants.

In: Kidney international, Vol. 92, No. 2, 08.2017, p. 297-305.

Research output: Contribution to journalArticle

KDIGO Controversies Conference on Challenges in the Conduct of Clinical Trials in Nephrology Conference Participants & KDIGO Controversies Conference on Challenges in the Conduct of Clinical Trials in Nephrology Conference Participants 2017, 'Challenges in conducting clinical trials in nephrology: conclusions from a Kidney Disease—Improving Global Outcomes (KDIGO) Controversies Conference', Kidney international, vol. 92, no. 2, pp. 297-305. https://doi.org/10.1016/j.kint.2017.04.019
KDIGO Controversies Conference on Challenges in the Conduct of Clinical Trials in Nephrology Conference Participants, KDIGO Controversies Conference on Challenges in the Conduct of Clinical Trials in Nephrology Conference Participants. Challenges in conducting clinical trials in nephrology: conclusions from a Kidney Disease—Improving Global Outcomes (KDIGO) Controversies Conference. Kidney international. 2017 Aug;92(2):297-305. https://doi.org/10.1016/j.kint.2017.04.019
KDIGO Controversies Conference on Challenges in the Conduct of Clinical Trials in Nephrology Conference Participants ; KDIGO Controversies Conference on Challenges in the Conduct of Clinical Trials in Nephrology Conference Participants. / Challenges in conducting clinical trials in nephrology : conclusions from a Kidney Disease—Improving Global Outcomes (KDIGO) Controversies Conference. In: Kidney international. 2017 ; Vol. 92, No. 2. pp. 297-305.
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