Challenges in biosensor development: Detection limit, detection time, and specificity

Some of the significant challenges faced in the development of biosensors are discussed. Some of these challenges include detection limit, detection time, and specificity. Detection time introduces significant challenges when designing biosensor systems, such as finding a suitable technology while maintaining the highest sensitivity and specificity. Specificity is considered the most essential quality of a biosensor, as it describes the sensor's ability to differentiate between target and non-targeted biological entities in a sample. The detection time of a sensor becomes significant when testing product quality on the production line in a food processing industry. The quality control test needs to be fast to reduce the cost of storage and minimize the delay before the product is introduced in the market. Efforts are also being made to reduce the detection limit of biosensors while keeping their sensitivity and reliability similar to that of conventional techniques.