CF-related diabetes: Containing the metabolic miscreant of cystic fibrosis

Research output: Contribution to journalReview articlepeer-review

22 Scopus citations

Abstract

Cystic fibrosis-related diabetes (CFRD) is associated with both an increase in morbidity and mortality in people with cystic fibrosis (CF). With increased screening and improved life expectancy of people with CF, the prevalence of CFRD is expected to rise further. The underlying pathophysiological mechanisms causing glucose intolerance and diabetes in patients with CF are not well understood but both functional and structural abnormalities in islet cells are likely to have key roles. Insulin therapy improves health outcomes in patients with CF. Future research is needed to better understand the mechanisms underlying the development of CFRD and to develop new screening and treatment strategies to minimize the detrimental impact of CFRD on health outcomes in people with CF.

Original languageEnglish (US)
Pages (from-to)S37-S43
JournalPediatric pulmonology
Volume52
DOIs
StatePublished - Nov 2017

Keywords

  • CFRD
  • cystic fibrosis
  • cystic fibrosis-related diabetes
  • glucose intolerance

Fingerprint Dive into the research topics of 'CF-related diabetes: Containing the metabolic miscreant of cystic fibrosis'. Together they form a unique fingerprint.

Cite this