Cervical Ectopic Pregnancy: Persistence Despite a Serologically Negative β-hCG. A Case Report

Shelly H. Tien, Yasuko Yamamura

Research output: Contribution to journalArticlepeer-review


BACKGROUND: Cervical pregnancy is a rare type of ectopic pregnancy that can be associated with significant hemorrhage and loss of fertility. Given its rarity, most effective treatment protocols are not well established.

CASE: A 33-year-old primigravid woman at 11 weeks' gestation presented to our institution with a cervical ectopic pregnancy with an initial β-hCG of 114,080 IU/L. She received 2 doses of systemic multidose methotrexate (1 mg/kg) with oral leucovorin on alternating days. Fetal intracardiac potassium chloride injection was also performed. Despite an appropriate decline to undetectable levels of serum β-hCG, as well as resumption of menses, there was persistent sonographic demonstration of the cervical ectopic pregnancy. Surgery was ultimately required to remove the ectopic products of conception.

CONCLUSION: Despite seemingly successful medical treatment of the cervical ectopic pregnancy with resultant undetectable serum β-hCG levels, surgery was necessary for complete resolution of the cervical pregnancy. This report supports the need to integrate both serum β-hCG levels and ultrasound to ensure complete resolution of these rare pregnancies.

Original languageEnglish (US)
Pages (from-to)257-260
Number of pages4
JournalThe Journal of reproductive medicine
Issue number5-6
StatePublished - May 1 2015


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