TY - JOUR
T1 - Cervical cancer screening
T2 - Evidence behind the guidelines
AU - Lees, Brittany F.
AU - Erickson, Britt K.
AU - Huh, Warner K.
N1 - Publisher Copyright:
© 2016 Elsevier Inc. All rights reserved.
PY - 2016/4/1
Y1 - 2016/4/1
N2 - Cervical cancer screening involves a complex process of cytology, human papillomavirus (HPV) testing, colposcopy, and a multitude of algorithms for the identification of preinvasive disease and prevention of invasive disease. High-risk HPV is a prerequisite for the development of almost all types of cervical cancer; therefore, a test for high-risk HPV has become an integral part of new screening strategies. Major changes to screening guidelines in the last decade include initiation of screening at age 21 years, conservative management of young women with abnormal cytology, extended screening intervals for women age ≥30 years, and cessation of screening in low-risk women at age 65 years. This review will focus on the evidence that has led to the current evidence-based guidelines. Evidence regarding primary HPV testing as well as postvaccine-based screening strategies will also be reviewed.
AB - Cervical cancer screening involves a complex process of cytology, human papillomavirus (HPV) testing, colposcopy, and a multitude of algorithms for the identification of preinvasive disease and prevention of invasive disease. High-risk HPV is a prerequisite for the development of almost all types of cervical cancer; therefore, a test for high-risk HPV has become an integral part of new screening strategies. Major changes to screening guidelines in the last decade include initiation of screening at age 21 years, conservative management of young women with abnormal cytology, extended screening intervals for women age ≥30 years, and cessation of screening in low-risk women at age 65 years. This review will focus on the evidence that has led to the current evidence-based guidelines. Evidence regarding primary HPV testing as well as postvaccine-based screening strategies will also be reviewed.
KW - cervical cancer screening
KW - colposcopy
KW - cytology
KW - human papillomavirus testing
KW - human papillomavirus vaccine
UR - http://www.scopus.com/inward/record.url?scp=84962106846&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84962106846&partnerID=8YFLogxK
U2 - 10.1016/j.ajog.2015.10.147
DO - 10.1016/j.ajog.2015.10.147
M3 - Review article
C2 - 26519782
AN - SCOPUS:84962106846
SN - 0002-9378
VL - 214
SP - 438
EP - 443
JO - American journal of obstetrics and gynecology
JF - American journal of obstetrics and gynecology
IS - 4
ER -
