Ceric ammonium nitrate (CAN) catalyzed ring cleavage of N-tosyl aziridines: A potential tool for solution phase library generation

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Abstract

A range of N-tosylaziridines is cleaved with NaN3, H2O, MeOH to synthesize vicinal azidoamines, aminols and amino ethers in good to excellent yields catalyzed by ceric ammonium nitrate and used in solution phase library synthesis.

Original languageEnglish (US)
Pages (from-to)7361-7363
Number of pages3
JournalTetrahedron Letters
Volume43
Issue number41
DOIs
StatePublished - Oct 7 2002
Externally publishedYes

Bibliographical note

Funding Information:
Two of us, C.N. and S.S.S., are thankful to CSIR, New Delhi for financial assistance.

Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.

Keywords

  • Ceric ammonium nitrate
  • Cleavage
  • HO
  • MeOH
  • N-substituted aziridines
  • NaN
  • Solution phase library
  • Vicinal azidoamines

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