Cerebrovascular disease in the era of left ventricular assist devices with continuous flow: Risk factors, diagnosis, and treatment

Joshua Z. Willey; Ryan T. Demmer; Hiroo Takayama; Paolo C. Colombo; Ronald M. Lazar

doi:10.1016/j.healun.2014.05.005

Cerebrovascular disease in the era of left ventricular assist devices with continuous flow: Risk factors, diagnosis, and treatment

Joshua Z. Willey, Ryan T. Demmer, Hiroo Takayama, Paolo C. Colombo, Ronald M. Lazar

Epidemiology & Community Health

Research output: Contribution to journal › Editorial › peer-review

73 Scopus citations

Abstract

Cerebral infarction and hemorrhage are among the principal sources of morbidity and mortality associated with mechanical circulatory support. There has been particular concern with the recently reported increased rate of device thrombosis in continuous-flow left ventricular assist devices. The neurologic management of stroke among these patients has limited data to inform current clinical practices. In this investigation we review the available literature on stroke in patients with continuous-flow left ventricular assist devices, with a focus on treatment algorithms in the acute setting and for secondary stroke prevention.

Original language	English (US)
Pages (from-to)	878-887
Number of pages	10
Journal	Journal of Heart and Lung Transplantation
Volume	33
Issue number	9
DOIs	https://doi.org/10.1016/j.healun.2014.05.005
State	Published - Sep 2014

Bibliographical note

Funding Information:
This study was supported by a grant from the National Institute of Neurological Disorders and Stroke (K23 NS 073104 to J.Z.W.). P.C.C. and R.M.L. contributed equally to this manuscript.

Keywords

acute stroke
epidemiology
intracerebral hemorrhage
ischemic stroke
left ventricular assist device
stroke prevention

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.healun.2014.05.005

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title = "Cerebrovascular disease in the era of left ventricular assist devices with continuous flow: Risk factors, diagnosis, and treatment",

abstract = "Cerebral infarction and hemorrhage are among the principal sources of morbidity and mortality associated with mechanical circulatory support. There has been particular concern with the recently reported increased rate of device thrombosis in continuous-flow left ventricular assist devices. The neurologic management of stroke among these patients has limited data to inform current clinical practices. In this investigation we review the available literature on stroke in patients with continuous-flow left ventricular assist devices, with a focus on treatment algorithms in the acute setting and for secondary stroke prevention.",

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author = "Willey, {Joshua Z.} and Demmer, {Ryan T.} and Hiroo Takayama and Colombo, {Paolo C.} and Lazar, {Ronald M.}",

note = "Funding Information: This study was supported by a grant from the National Institute of Neurological Disorders and Stroke (K23 NS 073104 to J.Z.W.). P.C.C. and R.M.L. contributed equally to this manuscript.",

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T2 - Risk factors, diagnosis, and treatment

AU - Willey, Joshua Z.

AU - Demmer, Ryan T.

AU - Takayama, Hiroo

AU - Colombo, Paolo C.

AU - Lazar, Ronald M.

N1 - Funding Information: This study was supported by a grant from the National Institute of Neurological Disorders and Stroke (K23 NS 073104 to J.Z.W.). P.C.C. and R.M.L. contributed equally to this manuscript.

PY - 2014/9

Y1 - 2014/9

N2 - Cerebral infarction and hemorrhage are among the principal sources of morbidity and mortality associated with mechanical circulatory support. There has been particular concern with the recently reported increased rate of device thrombosis in continuous-flow left ventricular assist devices. The neurologic management of stroke among these patients has limited data to inform current clinical practices. In this investigation we review the available literature on stroke in patients with continuous-flow left ventricular assist devices, with a focus on treatment algorithms in the acute setting and for secondary stroke prevention.

AB - Cerebral infarction and hemorrhage are among the principal sources of morbidity and mortality associated with mechanical circulatory support. There has been particular concern with the recently reported increased rate of device thrombosis in continuous-flow left ventricular assist devices. The neurologic management of stroke among these patients has limited data to inform current clinical practices. In this investigation we review the available literature on stroke in patients with continuous-flow left ventricular assist devices, with a focus on treatment algorithms in the acute setting and for secondary stroke prevention.

KW - acute stroke

KW - epidemiology

KW - intracerebral hemorrhage

KW - ischemic stroke

KW - left ventricular assist device

KW - stroke prevention

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Cerebrovascular disease in the era of left ventricular assist devices with continuous flow: Risk factors, diagnosis, and treatment

Abstract

Bibliographical note

Keywords

UN SDGs

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