Cerebral Ventricular Enlargement in Schizophrenia: A Preliminary Follow-up Study

Henry A. Nasrallah, Stephen C. Olson, Mona McCalley-Whitters, Suzanne Chapman, Charles G. Jacoby

Research output: Contribution to journalArticlepeer-review

119 Scopus citations


Lateral cerebral ventricular enlargement is now known to occur in some schizophrenic patients. To determine whether ventriculomegaly in schizophrenia is a static vs progressive process, we conducted a follow-up computed tomographic brain scan study on 11 young male patients, three years after initial scans were obtained. No significant change was found in the mean ventricles-brain ratio of this small schizophrenic sample after three years. Four of 11 patients showed noticeable increases (>;50%) in individual ratio. Methodologic problems are discussed and the need for follow-up studies as a research strategy is emphasized.

Original languageEnglish (US)
Pages (from-to)157-159
Number of pages3
JournalArchives of General Psychiatry
Issue number2
StatePublished - Feb 1986


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