Cerebral Sinus Venous Thrombosis in Infants After Surgery for Congenital Heart Disease

Dana B. Harrar, Margaret Goss, Mary T. Donofrio, Jonathan Murnick, Justus G. Reitz, Anqing Zhang, Yaser Diab, Jennifer Meldau, Pranava Sinha, Can Yerebakan, Jessica L. Carpenter

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


OBJECTIVE: To determine the prevalence of and risk factors for cerebral sinus venous thrombosis (CSVT) in neonates undergoing congenital heart disease (CHD) repair.

STUDY DESIGN: Neonates who had CHD repair with cardiopulmonary bypass and postoperative brain magnetic resonance imaging (MRI) between 2013 and 2019 at a single tertiary care center were identified from institutional databases. Demographic, clinical, and surgical data were abstracted from these databases and from the medical record; 278 neonates with CHD had cardiopulmonary bypass, 184 of whom had a postoperative brain MRI.

RESULTS: Eight patients (4.3%) had a CSVT. Transposition of the great arteries with an intact ventricular septum (P < .01) and interrupted aortic arch (P = .02) were associated with an increased risk for CSVT. Other risk factors for CSVT included cross-clamp time (98 [IQR, 77.5-120] minutes vs 67 [IQR, 44-102] minutes; P = .03), units of platelets (3.63 [IQR, 3-4] vs 2.17 [IQR, 1-4]; P < .01) and packed red blood cells (0.81 [IQR, 0.25-1] vs 1.21 [IQR, 1-1]; P = .03) transfused intraoperatively, and time between surgery and MRI (10 [IQR, 7-12.5] days vs 20 [IQR, 12-35] days; P < .01). Five patients (62.5%) were treated with anticoagulation. All patients had complete or partial resolution of their CSVT, regardless of treatment.

CONCLUSIONS: Brain MRI after cardiopulmonary bypass in neonates revealed a low prevalence of CSVT (4.3%). Further studies are needed to establish best practices for surveillance, prevention, and treatment of CSVT in this population.

Original languageEnglish (US)
JournalJournal of Pediatrics
StatePublished - Sep 2022

Bibliographical note

Publisher Copyright:
© 2022 Elsevier Inc.


  • cardiac surgery
  • magnetic resonance imaging
  • magnetic resonance venography
  • Transposition of Great Vessels/complications
  • Heart Defects, Congenital/complications
  • Venous Thrombosis/complications
  • Humans
  • Infant
  • Sinus Thrombosis, Intracranial/epidemiology
  • Anticoagulants/therapeutic use
  • Infant, Newborn

PubMed: MeSH publication types

  • Journal Article


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