Cerebral oxygen balance is impaired during repair of aortic coarctation in infants and children

Anthony Azakie, Jessica Muse, Marisa Gardner, Kimberly L. Skidmore, Steven P. Miller, Tom R. Karl, Patrick S. McQuillen

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21 Scopus citations

Abstract

Objective: During repair of aortic coarctation through a left thoracotomy without cardiopulmonary bypass, clamping the proximal transverse aortic arch occludes antegrade flow to the left carotid and vertebral arteries. It is assumed that flow through the right carotid and vertebral arteries is adequate for cerebral perfusion. The study objective is to determine whether aortic occlusion impairs left hemispheric cerebral oxygen balance measured by near-infrared spectroscopy. Methods: In 18 children having repair of aortic coarctation, we measured the maximum change and integral for hemoglobin D (difference of oxyhemoglobin and deoxyhemoglobin), total oxygenation index, and the redox state of cytochrome aa3. Thirteen subjects had recordings from the left hemisphere to test the hypothesis that aortic occlusion impairs left hemispheric oxygen balance. Five subjects had recordings from the right hemisphere for comparison. Results: After aortic clamping, a significant decrease in hemoglobin D was observed in recordings from the left hemisphere compared with those from the right hemisphere (P = .03, maximum change in hemoglobin D). Total oxygenation index and cytochrome aa3 were generally preserved. There was an inverse linear relationship for the change in hemoglobin D during clamp application and after removal (Spearman rho = -0.74), with increased hemoglobin D after clamp removal in those subjects with the greatest decrease of hemoglobin D during arch occlusion. Linear regression analysis identified nitroprusside administration as significantly associated with a decrease in hemoglobin D (P < .001). Conclusions: Significant impairment in left hemispheric cerebral oxygen balance was identified during arch clamping. The neurodevelopmental significance of impaired cerebral oxygen balance detected by near-infrared spectroscopy during aortic coarctation repair remains to be elucidated.

Original languageEnglish (US)
Pages (from-to)830-836
Number of pages7
JournalJournal of Thoracic and Cardiovascular Surgery
Volume130
Issue number3
DOIs
StatePublished - Sep 2005

Bibliographical note

Funding Information:
This work was supported by the UCSF School of Medicine Dean’s Summer Research Fellowship (J.M.) and the American Heart Association Undergraduate Student Research Program (M.G.). A UCSF School of Medicine Dean’s Office Research Evaluation and Allocation Committee shared equipment grant (P.M.) was used to purchase the Hamamatsu NIRO-300.

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