Cerebral oximetry during cardiac surgery: The association between cerebral oxygen saturation and perioperative patient variables

Ioanna Apostolidou, Greg Morrissette, Muhammad F. Sarwar, Mojca R. Konia, Vibhu R Kshettry, Joyce A. Wahr, Aaron A. Lobbestael, Nancy A. Nussmeier

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


Objective: This "real-world" study was designed to assess the patterns of regional cerebral oxygen saturation (rSO2) change during adult cardiac surgery. A secondary objective was to determine any relation between perioperative rSO2 (baseline and during surgery) and patient characteristics or intraoperative variables. Design: Prospective, observational, multicenter, nonrandomized clinical study. Setting: Cardiac operating rooms at 3 academic medical centers. Participants: Ninety consecutive adult patients presenting for cardiac surgery with or without cardiopulmonary bypass. Interventions: Patients received standard care at each institution plus bilateral forehead recordings of cerebral oxygen saturation with the 7600 Regional Oximeter System (Nonin Medical, Plymouth, MN). Measurements and Main Results: The average baseline (before induction) rSO2 was 63.9 ± 8.8% (range 41%-95%); preoperative hematocrit correlated with baseline rSO2 (0.48% increase for each 1% increase in hematocrit, p = 0.008). The average nadir (lowest recorded rSO2 for any given patient) was 54.9 ± 6.6% and was correlated with on-pump surgery, baseline rSO 2, and height. Baseline rSO2 was found to be an independent predictor of length of stay (hazard ratio 1.044, confidence interval 1.02-1.07, for each percentage of baseline rSO2). Conclusions: In cardiac surgical patients, lower baseline rSO2 value, on-pump surgery, and height were significant predictors of nadir rSO2, whereas only baseline rSO2 was a predictor of postoperative length of stay. These findings support previous research on the predictive value of baseline rSO2 on length of stay and emphasize the need for further research regarding the clinical relevance of baseline rSO2 and intraoperative changes.

Original languageEnglish (US)
Pages (from-to)1015-1021
Number of pages7
JournalJournal of Cardiothoracic and Vascular Anesthesia
Issue number6
StatePublished - Dec 2012

Bibliographical note

Funding Information:
Funding for this study was provided by Nonin Medical, Plymouth, MN.


  • cardiac surgery
  • cerebral oximetry
  • cerebral oxygen saturation
  • outcomes
  • oximetry


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