TY - JOUR
T1 - Cerebral hemodynamics in preeclampsia and eclampsia
AU - Qureshi, Adnan I.
AU - Frankel, Michael R.
AU - Ottenlips, Jeffrey R.
AU - Stern, Barney J.
N1 - Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 1996/12
Y1 - 1996/12
N2 - Objective: To test further the hypothesis that preeclampsia and eclampsia are associated with cerebral vasospasm. Design: Prospective case study. Setting: Inpatient obstetrics service of an urban public hospital. Patients and Methods: Eleven women with eclampsia (mean gestational age, 32 weeks), preeclampsia (mean gestational age, 36 weeks), or normotensive pregnancy (mean gestational age, 35 weeks). Middle cerebral artery (MCA) velocity was measured bilaterally in all patients by means of transcranial Doppler ultrasonography. Results: Eclamptic patients (n=3) had significantly higher mean flow velocities and lower average pulsatility indexes than did normotensive patients (n=4) (average MCA-mean flow velocity, 165 vs 79 cm/s [P=.007]; average MCA pulsatility index, 0.51 vs 1.1 [P<.001]). Compared with normotensive pregnant women, preeclamptic patients (n=4) had lower average pulsatility indexes (0.76, P=.003), but similar mean flow velocities (average MCA-mean flow velocity, 82 cm/s; P=.8). Conclusion: Significantly higher MCA velocities in eclamptic, but not preeclamptic, women compared with those in normotensive pregnant women suggests that moderate to severe vasospasm is associated with eclampsia.
AB - Objective: To test further the hypothesis that preeclampsia and eclampsia are associated with cerebral vasospasm. Design: Prospective case study. Setting: Inpatient obstetrics service of an urban public hospital. Patients and Methods: Eleven women with eclampsia (mean gestational age, 32 weeks), preeclampsia (mean gestational age, 36 weeks), or normotensive pregnancy (mean gestational age, 35 weeks). Middle cerebral artery (MCA) velocity was measured bilaterally in all patients by means of transcranial Doppler ultrasonography. Results: Eclamptic patients (n=3) had significantly higher mean flow velocities and lower average pulsatility indexes than did normotensive patients (n=4) (average MCA-mean flow velocity, 165 vs 79 cm/s [P=.007]; average MCA pulsatility index, 0.51 vs 1.1 [P<.001]). Compared with normotensive pregnant women, preeclamptic patients (n=4) had lower average pulsatility indexes (0.76, P=.003), but similar mean flow velocities (average MCA-mean flow velocity, 82 cm/s; P=.8). Conclusion: Significantly higher MCA velocities in eclamptic, but not preeclamptic, women compared with those in normotensive pregnant women suggests that moderate to severe vasospasm is associated with eclampsia.
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U2 - 10.1001/archneur.1996.00550120034013
DO - 10.1001/archneur.1996.00550120034013
M3 - Article
C2 - 8970450
AN - SCOPUS:0030480264
SN - 0003-9942
VL - 53
SP - 1226
EP - 1231
JO - Archives of Neurology
JF - Archives of Neurology
IS - 12
ER -