Cerebral Effects of Neonatal Dysglycemia

Megan E. Paulsen; Raghavendra B. Rao

doi:10.1016/j.clp.2022.02.008

Cerebral Effects of Neonatal Dysglycemia

Megan E. Paulsen, Raghavendra B. Rao

Neonatology (Pediatrics)

Research output: Contribution to journal › Review article › peer-review

2 Scopus citations

Abstract

This article summarizes the available evidence reporting the relationship between perinatal dysglycemia and long-term neurodevelopment. We review the physiology of perinatal glucose metabolism and discuss the controversies surrounding definitions of perinatal dysglycemia. We briefly review the epidemiology of hypoglycemia and hyperglycemia in fetal, preterm, and term infants. We discuss potential pathophysiologic mechanisms contributing to dysglycemia and its effect on neurodevelopment. We highlight current strategies to prevent and treat dysglycemia in the context of neurodevelopmental outcomes. Finally, we discuss areas of future research and the potential role of continuous glucose monitoring.

Original language	English (US)
Pages (from-to)	405-426
Number of pages	22
Journal	Clinics in Perinatology
Volume	49
Issue number	2
DOIs	https://doi.org/10.1016/j.clp.2022.02.008
State	Published - Jun 2022

Bibliographical note

Funding Information:
Dr M.E. Paulsen was supported by the National Institute of Health Building Interdisciplinary Research Careers in Women’s Health (BIRCWH) grant K12HD055887 .

Funding Information:
Dr M.E. Paulsen was supported by the National Institute of Health Building Interdisciplinary Research Careers in Women's Health (BIRCWH) grant K12HD055887.

Keywords

Blood glucose
Brain
Hyperglycemia
Hypoglycemia
Hypoxic-ischemic encephalopathy
Neurodevelopment
Perinatal
Preterm

PubMed: MeSH publication types

Journal Article
Review
Research Support, N.I.H., Extramural

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10.1016/j.clp.2022.02.008

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title = "Cerebral Effects of Neonatal Dysglycemia",

abstract = "This article summarizes the available evidence reporting the relationship between perinatal dysglycemia and long-term neurodevelopment. We review the physiology of perinatal glucose metabolism and discuss the controversies surrounding definitions of perinatal dysglycemia. We briefly review the epidemiology of hypoglycemia and hyperglycemia in fetal, preterm, and term infants. We discuss potential pathophysiologic mechanisms contributing to dysglycemia and its effect on neurodevelopment. We highlight current strategies to prevent and treat dysglycemia in the context of neurodevelopmental outcomes. Finally, we discuss areas of future research and the potential role of continuous glucose monitoring.",

keywords = "Blood glucose, Brain, Hyperglycemia, Hypoglycemia, Hypoxic-ischemic encephalopathy, Neurodevelopment, Perinatal, Preterm",

author = "Paulsen, {Megan E.} and Rao, {Raghavendra B.}",

note = "Funding Information: Dr M.E. Paulsen was supported by the National Institute of Health Building Interdisciplinary Research Careers in Women{\textquoteright}s Health (BIRCWH) grant K12HD055887 . Funding Information: Dr M.E. Paulsen was supported by the National Institute of Health Building Interdisciplinary Research Careers in Women's Health (BIRCWH) grant K12HD055887.",

year = "2022",

month = jun,

doi = "10.1016/j.clp.2022.02.008",

language = "English (US)",

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AU - Rao, Raghavendra B.

N1 - Funding Information: Dr M.E. Paulsen was supported by the National Institute of Health Building Interdisciplinary Research Careers in Women’s Health (BIRCWH) grant K12HD055887 . Funding Information: Dr M.E. Paulsen was supported by the National Institute of Health Building Interdisciplinary Research Careers in Women's Health (BIRCWH) grant K12HD055887.

PY - 2022/6

Y1 - 2022/6

N2 - This article summarizes the available evidence reporting the relationship between perinatal dysglycemia and long-term neurodevelopment. We review the physiology of perinatal glucose metabolism and discuss the controversies surrounding definitions of perinatal dysglycemia. We briefly review the epidemiology of hypoglycemia and hyperglycemia in fetal, preterm, and term infants. We discuss potential pathophysiologic mechanisms contributing to dysglycemia and its effect on neurodevelopment. We highlight current strategies to prevent and treat dysglycemia in the context of neurodevelopmental outcomes. Finally, we discuss areas of future research and the potential role of continuous glucose monitoring.

AB - This article summarizes the available evidence reporting the relationship between perinatal dysglycemia and long-term neurodevelopment. We review the physiology of perinatal glucose metabolism and discuss the controversies surrounding definitions of perinatal dysglycemia. We briefly review the epidemiology of hypoglycemia and hyperglycemia in fetal, preterm, and term infants. We discuss potential pathophysiologic mechanisms contributing to dysglycemia and its effect on neurodevelopment. We highlight current strategies to prevent and treat dysglycemia in the context of neurodevelopmental outcomes. Finally, we discuss areas of future research and the potential role of continuous glucose monitoring.

KW - Blood glucose

KW - Brain

KW - Hyperglycemia

KW - Hypoglycemia

KW - Hypoxic-ischemic encephalopathy

KW - Neurodevelopment

KW - Perinatal

KW - Preterm

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Cerebral Effects of Neonatal Dysglycemia

Abstract

Bibliographical note

Keywords

PubMed: MeSH publication types

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