Cerebral blood flow and regional potassium distribution during focal ischemia of gerbil brain

G. Mies, O. Kloiber, L. R. Drewes, K. ‐A Hossmann

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

In 8 gerbils (Meriones unguiculatus) focal cerebral ischemia was produced by occlusion of the left common carotid artery and the opposite external carotid artery. After two hours blood flow was measured with iodoantipyrine labeled with carbon 14, and evaluated by means of quantitative autoradiography. Thereafter the same brain sections were stained for regional potassium by means of a histochemical technique. Changes in tissue potassium content were assessed by measuring the differences in optical densities in homotopic brain regions of the stained sections. The correlation between blood flow and tissue potassium level revealed that below a flow threshold of about 0.23 ml/gm/min, a definite potassium loss from the tissue was observed. The combination of autoradiographic methods with a technique for measuring the regional distribution of potassium may be useful in providing additional information on the occurrence of disturbed electrolyte homeostasis after the onset of focal ischemia.

Original languageEnglish (US)
Pages (from-to)232-237
Number of pages6
JournalAnnals of Neurology
Volume16
Issue number2
DOIs
StatePublished - Aug 1984

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