Cerebellar Lobulus Simplex and Crus I Differentially Represent Phase and Phase Difference of Prefrontal Cortical and Hippocampal Oscillations

Samuel S. McAfee, Yu Liu, Roy V. Sillitoe, Detlef H. Heck

Research output: Contribution to journalArticlepeer-review

44 Scopus citations

Abstract

The cerebellum has long been implicated in tasks involving precise temporal control, especially in the coordination of movements. McAfee et al. show that the cerebellar principal neurons, Purkinje cells, represent precise temporal information about the phase and phase differences of neuronal oscillations occurring in two non-motor-related cerebral cortical structures.

Original languageEnglish (US)
Pages (from-to)2328-2334.e3
JournalCell reports
Volume27
Issue number8
DOIs
StatePublished - May 21 2019
Externally publishedYes

Bibliographical note

Funding Information:
We thank Shuhua Qi for technical assistance, Micheal Nguyen for custom machined parts, and Brittany Correia and Aspen Robinson for help with data analysis. Support was provided by the UTHSC College of Medicine , the Neuroscience Institute , and the Department Anatomy and Neurobiology . R.V.S. is supported by R01NS089664 , R01NS100874 , and U54HD083092 (Neuropathology Core) and D.H.H., R.V.S., and Y.L. are supported by R01MH112143 .

Funding Information:
We thank Shuhua Qi for technical assistance, Micheal Nguyen for custom machined parts, and Brittany Correia and Aspen Robinson for help with data analysis. Support was provided by the UTHSC College of Medicine, the Neuroscience Institute, and the Department Anatomy and Neurobiology. R.V.S. is supported by R01NS089664, R01NS100874, and U54HD083092 (Neuropathology Core)and D.H.H. R.V.S. and Y.L. are supported by R01MH112143. S.S.M. and D.H.H. conceived and developed the original research project, contributed to interpretation of the results, and wrote the manuscript. S.S.M. designed and implemented the data analysis procedures. Y.L. conducted the experiments and contributed to data pre-processing and editing of the manuscript. R.V.S. contributed to the development of the original research concept and edited the manuscript. The authors declare no competing interests.

Publisher Copyright:
© 2019 The Author(s)

Keywords

  • cerebro-cerebellar interaction
  • neuronal oscillation
  • oscillation phase
  • phase difference

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