Cerebellar hypoplasia and dysplasia in a juvenile raccoon with parvoviral infection

Arno Wünschmann, Robert Lopez-Astacio, Anibal G. Armien, Colin R. Parrish

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

A juvenile raccoon (Procyon lotor) was submitted dead to the Minnesota Veterinary Diagnostic Laboratory for rabies testing without history. The animal had marked hypoplasia of the cerebellum. Histology demonstrated that most folia lacked granule cells and had randomly misplaced Purkinje cells. Immunohistochemistry revealed the presence of parvoviral antigen in a few neurons and cell processes. PCR targeting feline and canine parvovirus yielded a positive signal. Sequencing analyses from a fragment of the nonstructural protein 1 (NS1) gene and a portion of the viral capsid protein 2 (VP2) gene confirmed the presence of DNA of a recent canine parvovirus variant (CPV-2a–like virus) in the cerebellum. Our study provides evidence that (canine) parvovirus may be associated with cerebellar hypoplasia and dysplasia in raccoons, similar to the disease that occurs naturally and has been reproduced experimentally by feline parvoviral infection of pregnant cats, with subsequent intrauterine or neonatal infections of the offspring.

Original languageEnglish (US)
Pages (from-to)463-466
Number of pages4
JournalJournal of Veterinary Diagnostic Investigation
Volume32
Issue number3
DOIs
StatePublished - May 1 2020

Keywords

  • Procyon lotor
  • cerebellar hypoplasia and dysplasia
  • parvovirus
  • raccoons

PubMed: MeSH publication types

  • Case Reports
  • Journal Article

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