Cerebellar Coordination of Neuronal Communication in Cerebral Cortex

Samuel S. McAfee, Yu Liu, Roy V. Sillitoe, Detlef H. Heck

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

Cognitive processes involve precisely coordinated neuronal communications between multiple cerebral cortical structures in a task specific manner. Rich new evidence now implicates the cerebellum in cognitive functions. There is general agreement that cerebellar cognitive function involves interactions between the cerebellum and cerebral cortical association areas. Traditional views assume reciprocal interactions between one cerebellar and one cerebral cortical site, via closed-loop connections. We offer evidence supporting a new perspective that assigns the cerebellum the role of a coordinator of communication. We propose that the cerebellum participates in cognitive function by modulating the coherence of neuronal oscillations to optimize communications between multiple cortical structures in a task specific manner.

Original languageEnglish (US)
Article number781527
JournalFrontiers in Systems Neuroscience
Volume15
DOIs
StatePublished - Jan 11 2022
Externally publishedYes

Bibliographical note

Funding Information:
SM was supported by American Lebanese Syrian Associated Charities, St. Jude Children’s Research Hospital. DH and YL were supported by R01MH112143, R01MH112143-02S1, and R37MH085726 and the University of Tennessee Neuroscience Institute. RS was supported by R01NS089664, R01NS100874, and 1P50HD103555.

Funding Information:
SM was supported by American Lebanese Syrian Associated Charities, St. Jude Children?s Research Hospital. DH and YL were supported by R01MH112143, R01MH112143-02S1, and R37MH085726 and the University of Tennessee Neuroscience Institute. RS was supported by R01NS089664, R01NS100874, and 1P50HD103555.

Publisher Copyright:
Copyright © 2022 McAfee, Liu, Sillitoe and Heck.

Keywords

  • cerebellum
  • cerebrocerebellar communication
  • cognition
  • coherence
  • functional connectivity

PubMed: MeSH publication types

  • Journal Article

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