Centrally administered μ- and δ-opioid agonists increase operant responding for saccharin

Blake A. Gosnell; Chetan K. Patel

doi:10.1016/0091-3057(93)90151-I

Centrally administered μ- and δ-opioid agonists increase operant responding for saccharin

Blake A. Gosnell, Chetan K. Patel

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

In previous reports, ICV administration of selective μ- or δ-opioid receptor agonists was found to stimulate the intake of saccharin and salt solutions in nondeprived rats. In the present study, we measured the effects of selective μ, δ, and κ-agonists on operant responding for saccharin. The selective μ-agonist [D-Ala²,N-Me-Phe⁴,Gly⁵-ol]-enkephalin (DAMGO) and the selective δ-agonist [D-Thr²]-leucine enkephalin-Thr (DTLET) increased responding, whereas the κ-agonist dynorphin A analog κ ligand (DAKLI) had no significant effect. These results agree with previous studies on saccharin and salt intake and are consistent with the possibility that the effects of opioids on the intake of these fluids are mediated via enhancement of activity in brain reward pathways.

Original language	English (US)
Pages (from-to)	979-982
Number of pages	4
Journal	Pharmacology, Biochemistry and Behavior
Volume	45
Issue number	4
DOIs	https://doi.org/10.1016/0091-3057(93)90151-I
State	Published - Aug 1993
Externally published	Yes

Keywords

Central injection
Operant
Opioid
Palatability
Reward
Saccharin
δ-Agonist
μ-Agonist

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10.1016/0091-3057(93)90151-I

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title = "Centrally administered μ- and δ-opioid agonists increase operant responding for saccharin",

abstract = "In previous reports, ICV administration of selective μ- or δ-opioid receptor agonists was found to stimulate the intake of saccharin and salt solutions in nondeprived rats. In the present study, we measured the effects of selective μ, δ, and κ-agonists on operant responding for saccharin. The selective μ-agonist [D-Ala2,N-Me-Phe4,Gly5-ol]-enkephalin (DAMGO) and the selective δ-agonist [D-Thr2]-leucine enkephalin-Thr (DTLET) increased responding, whereas the κ-agonist dynorphin A analog κ ligand (DAKLI) had no significant effect. These results agree with previous studies on saccharin and salt intake and are consistent with the possibility that the effects of opioids on the intake of these fluids are mediated via enhancement of activity in brain reward pathways.",

keywords = "Central injection, Operant, Opioid, Palatability, Reward, Saccharin, δ-Agonist, μ-Agonist",

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year = "1993",

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T1 - Centrally administered μ- and δ-opioid agonists increase operant responding for saccharin

AU - Gosnell, Blake A.

AU - Patel, Chetan K.

PY - 1993/8

Y1 - 1993/8

N2 - In previous reports, ICV administration of selective μ- or δ-opioid receptor agonists was found to stimulate the intake of saccharin and salt solutions in nondeprived rats. In the present study, we measured the effects of selective μ, δ, and κ-agonists on operant responding for saccharin. The selective μ-agonist [D-Ala2,N-Me-Phe4,Gly5-ol]-enkephalin (DAMGO) and the selective δ-agonist [D-Thr2]-leucine enkephalin-Thr (DTLET) increased responding, whereas the κ-agonist dynorphin A analog κ ligand (DAKLI) had no significant effect. These results agree with previous studies on saccharin and salt intake and are consistent with the possibility that the effects of opioids on the intake of these fluids are mediated via enhancement of activity in brain reward pathways.

AB - In previous reports, ICV administration of selective μ- or δ-opioid receptor agonists was found to stimulate the intake of saccharin and salt solutions in nondeprived rats. In the present study, we measured the effects of selective μ, δ, and κ-agonists on operant responding for saccharin. The selective μ-agonist [D-Ala2,N-Me-Phe4,Gly5-ol]-enkephalin (DAMGO) and the selective δ-agonist [D-Thr2]-leucine enkephalin-Thr (DTLET) increased responding, whereas the κ-agonist dynorphin A analog κ ligand (DAKLI) had no significant effect. These results agree with previous studies on saccharin and salt intake and are consistent with the possibility that the effects of opioids on the intake of these fluids are mediated via enhancement of activity in brain reward pathways.

KW - Central injection

KW - Operant

KW - Opioid

KW - Palatability

KW - Reward

KW - Saccharin

KW - δ-Agonist

KW - μ-Agonist

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SN - 0091-3057

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JO - Pharmacology Biochemistry and Behavior

JF - Pharmacology Biochemistry and Behavior

IS - 4

ER -

Centrally administered μ- and δ-opioid agonists increase operant responding for saccharin

Abstract

Keywords

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