Central retinal thickness is positively correlated with macular pigment optical density

S. H.Melissa Liew, Clare E. Gilbert, Tim D. Spector, John Mellerio, Frederik J.Van Kuijk, Stephen Beatty, Fred Fitzke, John Marshall, Christopher J. Hammond

Research output: Contribution to journalArticlepeer-review

58 Scopus citations


Macular pigment (MP) has been suggested to have a protective role in age-related macular degeneration by reducing the amount of oxidative stress on the retina. MP levels peak at the foveal center, where it is found predominantly in the receptor axon and inner plexiform layers of the retina. The purpose of this study was to investigate the relationship between central retinal thickness and macular pigment optical density in a group of healthy subjects. We report that macular pigment optical density (MPOD) has a significant and positive relationship with central retinal thickness as measured by optical coherence tomography. The strength of the observed relationship (r∼0.30) was independent of the technique used to measure MPOD, whether heterochromatic flicker photometry (HFP) or 2-wavelength autofluorescence (AF). Of note, there was no statistically demonstrable relationship between MPOD at an eccentricity of 1- or 2-degrees and central retinal thickness. This finding has important implications for future studies investigating MPOD, and its response to dietary modification/supplementation.

Original languageEnglish (US)
Pages (from-to)915-920
Number of pages6
JournalExperimental Eye Research
Issue number5
StatePublished - May 2006

Bibliographical note

Funding Information:
We are grateful to all the volunteers. Financial support was provided by the Wellcome Trust. The authors also thank Prof. Miles Stanford for his support of this research and use of the OCT machine.


  • Lutein, carotenoids
  • Macular pigment
  • Retinal thickness
  • Xanthophylls


Dive into the research topics of 'Central retinal thickness is positively correlated with macular pigment optical density'. Together they form a unique fingerprint.

Cite this