Cellular therapy for childhood neurodegenerative disease. Part II: Clinical trial design and implementation

Nathan R. Selden, Daniel J. Guillaume, Robert D. Steiner, Stephen L. Huhn

Research output: Contribution to journalReview article

21 Scopus citations

Abstract

Cellular replacement therapy attempts to improve functioning of the disease human central nervous system (CNS). In this second installment of a 2-part review, the authors discuss the major challenges to the translation of in vitro and animal studies of neural stem cell (NSC) therapy in the clinical setting. This analysis details the problems unique to the design of clinical trials using human NSCs, outlines patient selection practices, describes surgical techniques for cellular transplantation, and reviews the regulatory issues and ethical concerns in trials involving neurologically impaired children.

Original languageEnglish (US)
Article numberE22
JournalNeurosurgical focus
Volume24
Issue number3-4
DOIs
StatePublished - Mar 1 2008

Keywords

  • Cell replacements therapy
  • Cell transplantation
  • Central nervous system clinical trial
  • Neural stem cell
  • Neurodegenerative diease
  • Restorative neurosurgery

Fingerprint Dive into the research topics of 'Cellular therapy for childhood neurodegenerative disease. Part II: Clinical trial design and implementation'. Together they form a unique fingerprint.

  • Cite this