Cellular Senescence in Aging, Tissue Repair, and Regeneration

Maria Shvedova, Rex Jeya Rajkumar Samdavid Thanapaul, Elizabeth L Thompson, Laura J. Niedernhofer, Daniel S. Roh

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

SUMMARY: Society and our healthcare system are facing unprecedented challenges due to the expansion of the older population. As plastic surgeons, we can improve care of our older patients through understanding the mechanisms of aging that inevitably impact their outcomes and well-being. One of the major hallmarks of aging, cellular senescence, has recently become the focus of vigorous research in academia and industry. Senescent cells, which are metabolically active but in a state of stable cell cycle arrest, are implicated in causing aging and numerous age-related diseases. Further characterization of the biology of senescence revealed that it can be both detrimental and beneficial to organisms depending on tissue context and senescence chronicity. Here, we review the role of cellular senescence in aging, wound healing, tissue regeneration, and other domains relevant to plastic surgery. We also review the current state of research on therapeutics that modulate senescence to improve conditions of aging.

Original languageEnglish (US)
Pages (from-to)4S-11S
JournalPlastic and reconstructive surgery
Volume150
Issue number4S-2
DOIs
StatePublished - Oct 1 2022

Bibliographical note

Funding Information:
This work was supported by a grant from the NIA [R03AG067983]; the Laszlo N. Tauber Professorship in Surgery; and the Boston Claude D. Pepper Older Americans Independence Center (NIA) Research Education Core Award 5P30AG031679-10, subaward 115900 to Daniel S. Roh, and by grants to Laura Niedernhofer (R01 AG063543, U19 AG056278, and P01 AG062413).

Publisher Copyright:
Copyright © 2022 by the American Society of Plastic Surgeons.

Keywords

  • Aging
  • Cell Cycle Checkpoints
  • Cellular Senescence
  • Humans
  • Wound Healing

PubMed: MeSH publication types

  • Review
  • Journal Article

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